Xu Xuebin, Biswas Silpak, Gu Guimin, Elbediwi Mohammed, Li Yan, Yue Min
Department of Microbiology Laboratory, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
Institute of Veterinary Sciences & Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.
Antibiotics (Basel). 2020 Sep 30;9(10):660. doi: 10.3390/antibiotics9100660.
spp. are recognized as important foodborne pathogens globally. serovar Rissen is one of the important serovars linked with swine products in numerous countries and can transmit to humans by food chain contamination. Worldwide emerging . Rissen is considered as one of the most common pathogens to cause human salmonellosis. The objective of this study was to determine the antimicrobial resistance properties and patterns of Rissen isolates obtained from humans, animals, animal-derived food products, and the environment in China. Between 2016 and 2019, a total of 311 Rissen isolates from different provinces or province-level cities in China were included here. Bacterial isolates were characterized by serotyping and antimicrobial susceptibility testing. Minimum inhibitory concentration (MIC) values of 14 clinically relevant antimicrobials were obtained by broth microdilution method. . Rissen isolates from humans were found dominant (67%; 208/311). . Rissen isolates obtained from human patients were mostly found with diarrhea. Other . Rissen isolates were acquired from food (22%; 69/311), animals (8%; 25/311), and the environment (3%; 9/311). Most of the isolates were resistant to tetracycline, trimethoprim-sulfamethoxazole, chloramphenicol, streptomycin, s ceftriaxone, c ciprofloxacin, and azithromycin. In total, 92% of the . Rissen isolates were multidrug-resistant and ASSuT (27%), ACT (25%), ACSSuT (22%), ACSSuTAmc (11%), and ACSSuTFox (7%) patterns were among the most prevalent antibiotic resistance patterns found in this study. The widespread dissemination of antimicrobial resistance could have emerged from misuse of antimicrobial agents in animal husbandry in China. These findings could be useful for rational antimicrobial usage against Rissen infections.
沙门氏菌在全球范围内被公认为重要的食源性病原体。里森血清型是许多国家与猪肉制品相关的重要血清型之一，可通过食物链污染传播给人类。在全球范围内不断出现。里森血清型被认为是引起人类沙门氏菌病最常见的病原体之一。本研究的目的是确定从中国的人类、动物、动物源性食品和环境中分离出的里森血清型菌株的抗菌耐药特性和模式。2016年至2019年期间，共纳入了来自中国不同省份或省级城市的311株里森血清型菌株。通过血清分型和抗菌药敏试验对细菌分离株进行了鉴定。采用肉汤微量稀释法获得了14种临床相关抗菌药物的最低抑菌浓度（MIC）值。从人类分离出的里森血清型菌株占主导地位（67%；208/311）。从人类患者分离出的里森血清型菌株大多伴有腹泻。其他里森血清型菌株分别从食品（22%；69/311）、动物（8%；25/311）和环境（3%；9/311）中获得。大多数分离株对四环素、甲氧苄啶-磺胺甲恶唑、氯霉素、链霉素、头孢曲松、环丙沙星和阿奇霉素耐药。总的来说，92%的里森血清型菌株对多种药物耐药，ASSuT（27%）、ACT（25%）、ACSSuT（22%）、ACSSuTAmc（11%）和ACSSuTFox（7%）模式是本研究中最常见的抗生素耐药模式。抗菌药物耐药性的广泛传播可能源于中国畜牧业中抗菌药物的滥用。这些发现可能有助于合理使用抗菌药物来对抗里森血清型感染。
