Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
Biomolecules. 2020 Sep 30;10(10):1397. doi: 10.3390/biom10101397.
Hydroxytyrosol (HT) is an essential molecule isolated from the phenolic fraction of olive (). HT has been implicated for its health-stimulating effect mainly due to its antioxidative capacity. The current review summarises and discusses the available evidence, related to HT activities in wound healing enhancement. The literature search of related articles published within the year 2010 to 2020 was conducted using Medline via Ebscohost, Scopus, and Google Scholar databases. Studies were limited to in vitro research regarding the role of HT in wound closure, including anti-inflammation, antimicrobial, antioxidative, and its direct effect to the cells involved in wound healing. The literature search revealed 7136 potentially relevant records were obtained from the database search. Through the screening process, 13 relevant in vitro studies investigating the role of HT in wound repair were included. The included studies reported a proangiogenic, antioxidative, antiaging, anti-inflammatory and antimicrobial effect of HT. The current in vitro evidence-based review highlights the cellular and molecular action of HT in influencing positive outcomes toward wound healing. Based on this evidence, HT is a highly recommended bioactive compound to be used as a pharmaceutical product for wound care applications.
羟基酪醇 (HT) 是从橄榄中酚类部分分离出来的重要分子。由于其抗氧化能力，HT 被认为具有促进健康的作用。本综述总结和讨论了与 HT 在促进伤口愈合方面的活性相关的现有证据。使用 Medline 通过 Ebscohost、Scopus 和 Google Scholar 数据库对 2010 年至 2020 年内发表的相关文章进行了相关文章的检索。研究仅限于 HT 在伤口闭合中的作用的体外研究，包括抗炎、抗菌、抗氧化以及其对参与伤口愈合的细胞的直接作用。文献检索从数据库检索中获得了 7136 条潜在相关记录。通过筛选过程，纳入了 13 项关于 HT 在伤口修复中作用的相关体外研究。纳入的研究报告了 HT 的促血管生成、抗氧化、抗老化、抗炎和抗菌作用。目前基于体外证据的综述强调了 HT 对影响伤口愈合的正向结果的细胞和分子作用。基于这一证据，HT 是一种非常推荐的生物活性化合物，可作为用于伤口护理应用的药物产品使用。
