School of Health Professions, Institute of Physiotherapy, Zurich University of Applied Sciences, Katharina-Sulzer-Platz 9, 8401, Winterthur, Switzerland.
Department of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland.
Health Qual Life Outcomes. 2020 Oct 2;18(1):323. doi: 10.1186/s12955-020-01576-w.
Instrumental Activities of Daily Living (IADL) limitations are associated with reduced health-related quality of life for people with mild cognitive impairment (MCI). For these people, the assessment of IADL is crucial to the diagnostic process, as well as for the evaluation of new interventions addressing MCI. The Amsterdam IADL Questionnaire Short Version (A-IADL-Q-SV) is an established assessment tool with good psychometric properties that has been shown to be robust to cultural differences in Western countries. The aims of this study were to: (1) cross-culturally adapt and validate the A-IADL-Q-SV for the German-speaking population of Switzerland; (2) investigate its cultural comparability; and (3) evaluate further psychometric properties.
The A-IADL-Q-SV German was pretested on clinicians and participants in a memory clinic setting. The psychometric properties and cultural comparability of the questionnaire were investigated in memory clinic settings including participants with MCI or mild dementia, as well as participants with normal cognition recruited from the community. Item response theory (IRT) was applied to investigate measurement invariance by means of differential item functioning to assess item bias. Additionally, the test-retest reliability on scale level, the construct validity through hypothesis testing and the discriminant validity of the A-IADL-Q-SV German were evaluated.
Ninety-six informants of participants with normal cognition, MCI or mild dementia completed the A-IADL-Q-SV German. The basic assumptions for IRT scoring were met. No meaningful differential item functioning for culture was detected between the Swiss and Dutch reference samples. High test-retest reliability on scale level (ICC 0.93; 95% CI 0.9-0.96) was found. More than 75% of the observed correlations between the A-IADL-Q-SV German and clinical measures of cognition and functional status were found to be in the direction and of the magnitude hypothesized. The A-IADL-Q-SV German was shown to be able to discriminate between participants with normal cognition and MCI, as well as MCI and mild dementia.
The A-IADL-Q-SV German is a psychometrically robust measurement tool for a Swiss population with normal cognition, MCI and mild dementia. Thus, it provides a valuable tool to assess IADL functioning in clinical practices and research settings in Switzerland. Trial registration This study was registered retrospectively in July 2019 on ClinicalTrials.gov (NCT04012398).
日常生活活动能力（IADL）受限与轻度认知障碍（MCI）患者的健康相关生活质量下降有关。对于这些人来说，IADL 的评估对于诊断过程以及评估针对 MCI 的新干预措施至关重要。阿姆斯特丹 IADL 问卷短版（A-IADL-Q-SV）是一种经过良好验证的测量工具，具有良好的心理测量特性，并且在西方国家具有稳健的文化差异。本研究的目的是：（1）对瑞士德语人群进行跨文化适应性和验证；（2）研究其文化可比性；（3）评估进一步的心理测量特性。
在记忆诊所环境中，对临床医生和参与者进行了 A-IADL-Q-SV 德语的预测试。在包括 MCI 或轻度痴呆症患者以及从社区招募的认知正常参与者的记忆诊所环境中，研究了问卷的心理测量特性和文化可比性。应用项目反应理论（IRT）通过差异项目功能评估项目偏差来研究测量不变性。此外，还评估了 A-IADL-Q-SV 德语的量表水平重测信度、通过假设检验的结构效度和判别效度。
96 名认知正常、MCI 或轻度痴呆症参与者的知情者完成了 A-IADL-Q-SV 德语。IRT 评分的基本假设得到满足。在瑞士和荷兰参考样本之间未发现具有文化意义的差异项目功能。在量表水平上发现了较高的重测信度（ICC 0.93；95%CI 0.9-0.96）。A-IADL-Q-SV 德语与认知和功能状态的临床测量之间观察到的超过 75%的相关性均朝着假设的方向和幅度发展。A-IADL-Q-SV 德语能够区分认知正常、MCI 以及 MCI 和轻度痴呆症患者。
A-IADL-Q-SV 德语是一种针对具有认知正常、MCI 和轻度痴呆症的瑞士人群的心理测量可靠的测量工具。因此，它为评估瑞士临床实践和研究环境中的 IADL 功能提供了有价值的工具。
本研究于 2019 年 7 月在 ClinicalTrials.gov（NCT04012398）上进行了回顾性注册。
