Fabarius Jonathan Thomas, Wegat Vanessa, Roth Arne, Sieber Volker
Fraunhofer Institute for Interfacial Engineering and Biotechnology, Straubing Branch Biocat, Straubing, Germany.
Fraunhofer Institute for Interfacial Engineering and Biotechnology, Straubing Branch Biocat, Straubing, Germany; Campus Straubing for Biotechnology and Sustainability, Technical University of Munich, Straubing, Germany.
Trends Biotechnol. 2021 Apr;39(4):348-358. doi: 10.1016/j.tibtech.2020.08.008. Epub 2020 Sep 29.
Mitigating climate change is a key driver for the development of sustainable and CO-neutral production processes. In this regard, connecting carbon capture and utilization processes to derive microbial C fermentation substrates from CO is highly promising. This strategy uses methylotrophic microbes to unlock next-generation processes, converting CO-derived methanol. Synthetic biology approaches in particular can empower synthetic methylotrophs to produce a variety of commodity chemicals. We believe that yeasts have outstanding potential for this purpose, because they are able to separate toxic intermediates and metabolic reactions in organelles. This compartmentalization can be harnessed to design superior synthetic methylotrophs, capable of utilizing methanol and other hitherto largely disregarded C compounds, thus supporting the establishment of a future circular economy.
缓解气候变化是可持续和碳中和生产工艺发展的关键驱动力。在这方面，将碳捕获和利用工艺连接起来，从一氧化碳中获取微生物碳发酵底物极具前景。该策略利用甲基营养型微生物开启下一代工艺，将一氧化碳转化为甲醇。尤其是合成生物学方法能够使合成甲基营养型微生物生产多种商品化学品。我们认为酵母在这方面具有巨大潜力，因为它们能够将有毒中间体和代谢反应分隔在细胞器中。这种区室化可用于设计出更优的合成甲基营养型微生物，使其能够利用甲醇和其他迄今大多被忽视的碳化合物，从而助力未来循环经济的建立。
