• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

外排泵作为控制耐药菌感染的干预手段。

Efflux pumps as interventions to control infection caused by drug-resistance bacteria.

作者信息

Farhat Nabeela, Ali Abid, Bonomo Robert A, Khan Asad U

机构信息

Medical Microbiology and Molecular Biology Lab, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India.

Louis Stokes Cleveland Department of Veteran Affairs Medical Center, Case Western Reserve University, Cleveland, OH, USA.

出版信息

Drug Discov Today. 2020 Dec;25(12):2307-2316. doi: 10.1016/j.drudis.2020.09.028. Epub 2020 Oct 1.

DOI:10.1016/j.drudis.2020.09.028
PMID:33011344
Abstract

Antibiotic resistance has become a global concern for healthcare workers and physicians. Efflux pumps are one of the major mechanisms of resistance. Hence, we describe examples of natural efflux pump inhibitors used to combat antibiotic resistance.

摘要

抗生素耐药性已成为医护人员和医生关注的全球性问题。外排泵是主要的耐药机制之一。因此，我们描述了用于对抗抗生素耐药性的天然外排泵抑制剂的实例。

相似文献

1
Efflux pumps as interventions to control infection caused by drug-resistance bacteria.外排泵作为控制耐药菌感染的干预手段。
Drug Discov Today. 2020 Dec;25(12):2307-2316. doi: 10.1016/j.drudis.2020.09.028. Epub 2020 Oct 1.
2
Efflux Pump Inhibitors: A Novel Approach to Combat Efflux-Mediated Drug Resistance in Bacteria.外排泵抑制剂：一种对抗细菌外排介导耐药性的新方法。
Curr Drug Targets. 2016;17(6):702-19. doi: 10.2174/1389450116666151001103948.
3
Medicinal Chemistry Updates on Bacterial Efflux Pump Modulators.细菌外排泵调节剂的药物化学最新进展。
Curr Med Chem. 2018;25(42):6030-6069. doi: 10.2174/0929867325666180209142612.
4
[Efflux pumps: their role in Staphylococcus aureus antibiotic resistance].[外排泵：它们在金黄色葡萄球菌抗生素耐药性中的作用]
Ann Biol Clin (Paris). 2008 Sep-Oct;66(5):499-508. doi: 10.1684/abc.2008.0266.
5
Bacterial Multidrug Efflux Pumps of the Major Facilitator Superfamily as Targets for Modulation.主要易化子超家族的细菌多药外排泵作为调控靶点
Infect Disord Drug Targets. 2016;16(1):28-43. doi: 10.2174/1871526516666160407113848.
6
Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance.鉴定周质衔接蛋白（PAP）与 RND 外排泵之间的结合残基，解释了 PAP 泵的混杂性及其在抗菌药物耐药性中的作用。
PLoS Pathog. 2019 Dec 26;15(12):e1008101. doi: 10.1371/journal.ppat.1008101. eCollection 2019 Dec.
7
A comprehensive review on pharmacology of efflux pumps and their inhibitors in antibiotic resistance.抗生素耐药性中外排泵及其抑制剂的药理学的全面综述。
Eur J Pharmacol. 2021 Jul 15;903:174151. doi: 10.1016/j.ejphar.2021.174151. Epub 2021 May 5.
8
An overview of bacterial efflux pumps and computational approaches to study efflux pump inhibitors.细菌外排泵及研究外排泵抑制剂的计算方法概述
Future Med Chem. 2016;8(2):195-210. doi: 10.4155/fmc.15.173. Epub 2016 Jan 29.
9
Current Advances in Developing Inhibitors of Bacterial Multidrug Efflux Pumps.细菌多药外排泵抑制剂开发的当前进展
Curr Med Chem. 2016;23(10):1062-81. doi: 10.2174/0929867323666160304150522.
10
An original deal for new molecule: reversal of efflux pump activity, a rational strategy to combat gram-negative resistant bacteria.一种新分子的原创交易：逆转外排泵活性，对抗革兰氏阴性耐药菌的合理策略。
Curr Med Chem. 2011;18(19):2969-80. doi: 10.2174/092986711796150469.

引用本文的文献

1
Inhibition of efflux pumps by FDA-approved drugs oxiconazole and sertaconazole restores antibiotic susceptibility in multidrug-resistant .美国食品药品监督管理局（FDA）批准的药物奥昔康唑和舍他康唑对流出泵的抑制作用可恢复多重耐药菌的抗生素敏感性。
Antimicrob Agents Chemother. 2025 Sep 3;69(9):e0032025. doi: 10.1128/aac.00320-25. Epub 2025 Aug 4.
2
Advancements in Antimicrobial Surface Coatings Using Metal/Metaloxide Nanoparticles, Antibiotics, and Phytochemicals.使用金属/金属氧化物纳米颗粒、抗生素和植物化学物质的抗菌表面涂层的进展
Nanomaterials (Basel). 2025 Jul 1;15(13):1023. doi: 10.3390/nano15131023.
3
Unlocking the Gates: A Novel Diagnostic Molecule for Quantifying Efflux Levels in Gram-Positive Bacteria.
开启大门：一种用于量化革兰氏阳性菌外排水平的新型诊断分子。
Adv Healthc Mater. 2025 Apr;14(11):e2404145. doi: 10.1002/adhm.202404145. Epub 2025 Mar 11.
4
Transient comparison of techniques to counter multi-drug resistant bacteria: prime modules in curation of bacterial infections.对抗多重耐药菌技术的瞬态比较：细菌感染管理中的主要模块
Front Antibiot. 2024 Jan 26;2:1309107. doi: 10.3389/frabi.2023.1309107. eCollection 2023.
5
Cholera Outbreaks in Zimbabwe: An In-Depth Analysis of Drivers, Constraints and Reimagining the Use of Medicinal Plants.津巴布韦的霍乱疫情：对驱动因素、制约因素的深入分析以及对药用植物利用的重新构想
J Trop Med. 2024 Nov 21;2024:1981991. doi: 10.1155/jotm/1981991. eCollection 2024.
6
Nanomedicines as a cutting-edge solution to combat antimicrobial resistance.纳米药物作为对抗抗菌耐药性的前沿解决方案。
RSC Adv. 2024 Oct 22;14(45):33568-33586. doi: 10.1039/d4ra06117a. eCollection 2024 Oct 17.
7
Whole-Genome Sequencing of a Colistin-Resistant Strain Isolated at a Tertiary Health Facility in Pretoria, South Africa.在南非比勒陀利亚一家三级医疗机构分离出的耐黏菌素菌株的全基因组测序
Antibiotics (Basel). 2022 Apr 28;11(5):594. doi: 10.3390/antibiotics11050594.
8
Fabrication of Curcumin@Ag Loaded Core/Shell Nanofiber Membrane and its Synergistic Antibacterial Properties.姜黄素@银负载核/壳纳米纤维膜的制备及其协同抗菌性能。
Front Chem. 2022 Mar 16;10:870666. doi: 10.3389/fchem.2022.870666. eCollection 2022.
9
Luteolin increases susceptibility to macrolides by inhibiting MsrA efflux pump in Trueperella pyogenes.木樨草素通过抑制酿脓链球菌的 MsrA 外排泵增加大环内酯类药物的敏感性。
Vet Res. 2022 Jan 10;53(1):3. doi: 10.1186/s13567-021-01021-w.
10
Efflux Pump Mediated Antimicrobial Resistance by Staphylococci in Health-Related Environments: Challenges and the Quest for Inhibition.健康相关环境中葡萄球菌外排泵介导的抗菌耐药性：挑战与抑制探索
Antibiotics (Basel). 2021 Dec 7;10(12):1502. doi: 10.3390/antibiotics10121502.