Department of Veterinary Microbiology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, South Korea.
Department of Infectious Diseases, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, South Korea.
Prev Vet Med. 2020 Nov;184:105151. doi: 10.1016/j.prevetmed.2020.105151. Epub 2020 Sep 25.
Transferring antimicrobial-resistant bacteria from companion animals to human hosts has become increasingly common. Data regarding antimicrobial susceptibility could help veterinarians to select the most appropriate antibiotic treatment. However, standardized and ongoing surveys regarding antimicrobial resistance remain limited. In this study, we investigated the antimicrobial-susceptibility patterns and trends of bacteria isolated from stray dogs, hospital-admitted dogs, and veterinary staff in South Korea from 2018 to 2019. The minimum inhibitory concentrations of different antimicrobials for Staphylococcus spp., Enterobacterales, and Enterococcus spp. were determined to establish representatives of different antibiotic classes relevant for treatment or surveillance. For coagulase-positive and -negative Staphylococci, resistance to gentamicin was <27 %, while that to ampicillin and penicillin was high (33-80 %). The mecA-detection rates among staphylococcal isolates were 28.5 %, 42.6 %, and 32 % from stray dogs, hospital-admitted dogs, and veterinary staffs, respectively. For Enterobacterales, resistance to carbapenems was low (0-6%). A total of 31.2 % and 18.9 % of Enterobacterales isolates from stray dogs and hospital-admitted dogs were confirmed to possess at least one of bla, bla, or bla. Additionally, Enterococcus spp. isolates showed no resistance to vancomycin. These results demonstrate that dogs are commonly colonized with antimicrobial-resistant bacteria and highlight the need for further investigation.
从伴侣动物向人类宿主转移抗菌药物耐药菌的现象越来越普遍。关于抗菌药物敏感性的数据可以帮助兽医选择最合适的抗生素治疗方案。然而，关于抗菌药物耐药性的标准化和持续调查仍然有限。在这项研究中，我们调查了 2018 年至 2019 年期间从韩国流浪狗、住院狗和兽医人员中分离的细菌的抗菌敏感性模式和趋势。测定了不同抗菌药物对葡萄球菌属、肠杆菌科和肠球菌属的最低抑菌浓度，以确定不同抗生素类别中与治疗或监测相关的代表性药物。对于凝固酶阳性和阴性葡萄球菌，对庆大霉素的耐药率<27%，而对氨苄西林和青霉素的耐药率较高（33-80%）。从流浪狗、住院狗和兽医人员中分离的葡萄球菌分离株中 mecA 的检出率分别为 28.5%、42.6%和 32%。对于肠杆菌科，对碳青霉烯类的耐药率较低（0-6%）。从流浪狗和住院狗中分离的肠杆菌科分离株中，分别有 31.2%和 18.9%被证实携带至少一种 bla、bla 或 bla 基因。此外，肠球菌属分离株对万古霉素没有耐药性。这些结果表明，狗通常定植有抗菌药物耐药菌，需要进一步调查。
