Translational Allergic Immunopathology Unit, Laboratory of Allergic Diseases, National Institutes of Health, 9000 Rockville Pike, Building 29B, Room 5NN18, MSC 1889, Bethesda, MD 20892, USA.
Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, BG 10 RM 11N244B, 10 Center Drive, Bethesda, MD 20814, USA.
Immunol Allergy Clin North Am. 2020 Nov;40(4):667-685. doi: 10.1016/j.iac.2020.06.007. Epub 2020 Sep 12.
Mast cells are tissue-resident allergic effector cells that cause many symptoms associated with IgE-mediated immediate hypersensitivity reactions. Beginning with allergen-specific therapy over a century ago, biologics have been used to target mast cells in patients in order to reduce allergic symptoms and reactions. This review discusses the history and current outlook of the use of biologics in mast cell-associated diseases and reactions.
肥大细胞是组织驻留的过敏性效应细胞，可引起许多与 IgE 介导的即刻超敏反应相关的症状。从一个多世纪前的过敏原特异性治疗开始，生物制剂就被用于靶向患者体内的肥大细胞，以减少过敏症状和反应。本文讨论了生物制剂在肥大细胞相关疾病和反应中的应用的历史和现状。
