Hung Yin P, Chirieac Lucian R
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Thorac Surg Clin. 2020 Nov;30(4):367-382. doi: 10.1016/j.thorsurg.2020.08.007.
Despite multiple diagnostic toolkits, the diagnosis of diffuse malignant pleural mesothelioma relies primarily on proper histologic assessment. The definitive diagnosis of diffuse malignant pleural mesothelioma is based on the pathologic assessment of tumor tissue, which can be obtained from core biopsy sampling, pleurectomy, or other more extensive resections, such as extrapleural pneumonectomy. Given its rarity and overlapping microscopic features with other conditions, the histologic diagnosis of diffuse malignant pleural mesothelioma is challenging. This review discusses the pathologic features and the differential diagnosis of diffuse malignant pleural mesothelioma, including select diagnostic pitfalls.
尽管有多种诊断工具包，但弥漫性恶性胸膜间皮瘤的诊断主要依赖于恰当的组织学评估。弥漫性恶性胸膜间皮瘤的确诊基于肿瘤组织的病理评估，肿瘤组织可通过芯针活检取样、胸膜切除术或其他更广泛的切除术获取，如胸膜外全肺切除术。鉴于其罕见性以及与其他病症在显微镜下特征的重叠，弥漫性恶性胸膜间皮瘤的组织学诊断具有挑战性。本文综述讨论了弥漫性恶性胸膜间皮瘤的病理特征和鉴别诊断，包括一些诊断陷阱。
