Instituto International de Pesquisa, A.C. Camargo Cancer Center, São Paulo (SP), Brasil.
Instituto Nacional de Oncogenômica e Inovação Terapêutica, São Paulo (SP), Brasil.
J Bras Pneumol. 2021 Dec 13;47(6):e20210129. doi: 10.36416/1806-3756/e20210129. eCollection 2021.
Malignant mesotheliomas are rare types of cancers that affect the mesothelial surfaces, usually the pleura and peritoneum. They are associated with asbestos exposure, but due to a latency period of more than 30 years and difficult diagnosis, most cases are not detected until they reach advanced stages. Treatment options for this tumor type are very limited and survival ranges from 12 to 36 months. This review discusses the molecular physiopathology, current diagnosis, and latest therapeutic options for this disease.
恶性间皮瘤是一种罕见的癌症，影响间皮表面，通常是胸膜和腹膜。它们与石棉暴露有关，但由于潜伏期超过 30 年且诊断困难，大多数病例在达到晚期阶段之前都无法检测到。这种肿瘤类型的治疗选择非常有限，存活时间从 12 到 36 个月不等。本文综述了该疾病的分子病理生理学、当前诊断和最新治疗选择。
