增强侧流分析法的灵敏度及其在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）检测中的应用
Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2.
作者信息
Peng Tao, Liu Xiangpei, Adams L Garry, Agarwal Girish, Akey Bruce, Cirillo Jeffrey, Deckert Volker, Delfan Sahar, Fry Edward, Han Zehua, Hemmer Philip, Kattawar George, Kim Moochan, Lee Ming-Che, Lu Chaoyang, Mogford Jon, Nessler Reed, Neuman Ben, Nie Xiaoyu, Pan Jianwei, Pryor Jane, Rajil Navid, Shih Yanhua, Sokolov Alexei, Svidzinsky Anatoly, Wang Dawei, Yi Zhenhuan, Zheltikov Aleksei, Scully Marlan
机构信息
Texas A&M University, College Station, Texas 77843, USA.
University of Science and Technology of China, Hefei 230026, China.
出版信息
Appl Phys Lett. 2020 Sep 21;117(12):120601. doi: 10.1063/5.0021842.
Lateral flow assay (LFA) has long been used as a biomarker detection technique. It has advantages such as low cost, rapid readout, portability, and ease of use. However, its qualitative readout process and lack of sensitivity are limiting factors. We report a photon-counting approach to accurately quantify LFAs while enhancing sensitivity. In particular, we demonstrate that the density of SARS-CoV-2 antibodies can be quantified and measured with an enhanced sensitivity using this simple laser optical analysis.
侧向流动分析（LFA）长期以来一直被用作生物标志物检测技术。它具有成本低、读数快速、便携和使用方便等优点。然而，其定性读数过程和缺乏灵敏度是限制因素。我们报告了一种光子计数方法，用于在提高灵敏度的同时准确量化LFA。特别是，我们证明使用这种简单的激光光学分析可以提高灵敏度来量化和测量新冠病毒抗体的密度。
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