瓜氨酸，一种辐射诱导小肠损伤的潜在生物标志物。
Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage.
作者信息
Ye Fei, Ning Jing, Fardous Zeenath, Katsube Takanori, Li Qiang, Wang Bing
机构信息
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, People's Republic of China.
Gansu Provincial Hospital, Lanzhou, People's Republic of China.
出版信息
Dose Response. 2020 Sep 22;18(3):1559325820962341. doi: 10.1177/1559325820962341. eCollection 2020 Jul-Sep.
Abstract
Radiation damage assessment of the small intestine is important in nuclear accidents or routine radiotherapy of abdominal tumors. This article reviews the clinical symptoms and molecular mechanisms of radiation-induced small intestinal damage and summarizes recent research on biomarkers of such damage. Citrulline is the most promising biomarker for the evaluation of radiation-induced small intestinal damage caused by radiotherapy and nuclear accidents. This article also summarizes the factors influencing plasma citrulline measurement investigated in the latest research, as well as new findings on the concentration of citrulline in saliva and urine after different types of radiation.
摘要
小肠的辐射损伤评估在核事故或腹部肿瘤的常规放射治疗中很重要。本文综述了辐射诱导的小肠损伤的临床症状和分子机制，并总结了近期关于此类损伤生物标志物的研究。瓜氨酸是评估放疗和核事故所致辐射诱导小肠损伤最有前景的生物标志物。本文还总结了最新研究中探讨的影响血浆瓜氨酸测量的因素，以及不同类型辐射后唾液和尿液中瓜氨酸浓度的新发现。
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