Salimi Amir, Zali Alireza, Seddighi Amir Saeid, Seddighi Afsoun, Meshkat Shakila, Hosseini Morteza, Nikouei Amir, Akbari Mohammad Esmaeil
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Functional Neurosurgical Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Cancer Epidemiol. 2020 Sep 18;2020:3534641. doi: 10.1155/2020/3534641. eCollection 2020.
Central nervous system (CNS) tumours account for only 1-2% of cancer incidence but are a major reason for mortality and morbidity due to malignancies. Recent studies show an increase in the rate of CNS tumours worldwide, especially in developing countries. Moreover, there is significant heterogeneity in epidemiological patterns worldwide. This study is aimed at representing nationwide epidemiology of CNS tumours in Iran.
Iran National Cancer Registry 2010-2014 data were reviewed for CNS tumours. The epidemiological rates were calculated for both genders and all age groups using the 2011 census information.
Out of 17345 cases, 58.5% were men and 41.5% were women. The mean age was 45.55 years ranging from less than 1 month to 100 years old. Average total age-standardized incidence rate (ASR) was 5.19 for primary tumours. The annual percent change (APC) was 14.23% during the study period. The most frequent site and histology recorded were brain, NOS and diffuse astrocytic, respectively. Geographical distribution showed about five-fold difference in ASRs between different provinces.
The overall ASR calculated was higher than the global rate in 2012 but lower than that of most developed countries, showing an increasing trend which may be due to either advances in diagnosing or risk factor augmentation. The mean age and incident rates were higher than those of previous reports in Iran.
中枢神经系统（CNS）肿瘤仅占癌症发病率的1%-2%，但却是恶性肿瘤导致死亡和发病的主要原因。最近的研究表明，全球中枢神经系统肿瘤的发病率有所上升，尤其是在发展中国家。此外，全球流行病学模式存在显著异质性。本研究旨在呈现伊朗全国范围内中枢神经系统肿瘤的流行病学情况。
回顾了伊朗国家癌症登记处2010-2014年中枢神经系统肿瘤的数据。利用2011年人口普查信息计算了男女及所有年龄组的流行病学发病率。
在17345例病例中，男性占58.5%，女性占41.5%。平均年龄为45.55岁，范围从不到1个月到100岁。原发性肿瘤的平均总年龄标准化发病率（ASR）为5.19。研究期间的年变化百分比（APC）为14.23%。记录的最常见部位和组织学类型分别是脑，未特指（NOS）和弥漫性星形细胞肿瘤。地理分布显示不同省份之间的年龄标准化发病率相差约五倍。
计算得出的总体年龄标准化发病率高于2012年的全球发病率，但低于大多数发达国家，呈上升趋势，这可能是由于诊断技术的进步或危险因素增加所致。平均年龄和发病率高于伊朗此前报告中的数据。
