Zhang Xinmu, Li Lin
Department of Medical Oncology, Beijing Hospital, National Center of Gerontology, Beijing, China.
Aging Dis. 2020 Oct 1;11(5):1329-1338. doi: 10.14336/AD.2019.1021. eCollection 2020 Oct.
Aging is a common risk factor for the occurrence and development of many diseases, such as Parkinson's disease, Alzheimer's disease, diabetes, hypertension, atherosclerosis and coronary heart disease, and cancer, among others, and is a key problem threatening the health and life expectancy of the elderly. Oxidative damage is an important mechanism involved in aging. The latest discovery pertaining to oxidative damage is that 8-oxoGsn (8-oxo-7,8-dihydroguanosine), an oxidative damage product of RNA, can represent the level of oxidative stress. The significance of RNA oxidative damage to aging has not been fully explained, but the relationship between the accumulation of 8-oxoGsn, a marker of RNA oxidative damage, and the occurrence of diseases has been confirmed in many aging-related diseases. Studying the aging mechanism, monitoring the aging level of the body and exploring the corresponding countermeasures are of great significance for achieving healthy aging and promoting public health and social development. This article reviews the progress of research on 8-oxoGsn in aging-related diseases.
衰老 是许多疾病发生和发展的常见风险因素，如帕金森病、阿尔茨海默病、糖尿病、高血压、动脉粥样硬化和冠心病以及癌症等，是威胁老年人健康和预期寿命的关键问题。氧化损伤是衰老过程中的一个重要机制。关于氧化损伤的最新发现是，RNA的氧化损伤产物8-氧代鸟嘌呤核苷（8-oxo-7,8-dihydroguanosine，8-oxoGsn）可代表氧化应激水平。RNA氧化损伤对衰老的意义尚未完全阐明，但RNA氧化损伤标志物8-oxoGsn的积累与多种衰老相关疾病的发生之间的关系已得到证实。研究衰老机制、监测机体衰老水平并探索相应对策，对于实现健康衰老、促进公众健康和社会发展具有重要意义。本文综述了8-oxoGsn在衰老相关疾病中的研究进展。
