Zhang Hantao, Liu Xiaoyan, Liu Yi, Liu Junlin, Gong Xun, Li Gang, Tang Min
School of Life Sciences, Jiangsu University, Zhenjiang, China.
Institute of Animal Husbandry, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Front Aging Neurosci. 2022 Aug 9;14:975248. doi: 10.3389/fnagi.2022.975248. eCollection 2022.
Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease, which imposes an ever-increasing burden on society. Many studies have indicated that oxidative stress may play an important role in Parkinson's disease through multiple processes related to dysfunction or loss of neurons. Besides, several subtypes of non-coding RNAs are found to be involved in this neurodegenerative disorder. However, the interplay between oxidative stress and regulatory non-coding RNAs in Parkinson's disease remains to be clarified. In this article, we comprehensively survey and overview the role of regulatory ncRNAs in combination with oxidative stress in Parkinson's disease. The interaction between them is also summarized. We aim to provide readers with a relatively novel insight into the pathogenesis of Parkinson's disease, which would contribute to the development of pre-clinical diagnosis and treatment.
帕金森病是仅次于阿尔茨海默病的第二常见神经退行性疾病，给社会带来日益沉重的负担。许多研究表明，氧化应激可能通过与神经元功能障碍或丧失相关的多个过程在帕金森病中发挥重要作用。此外，发现几种非编码RNA亚型参与了这种神经退行性疾病。然而，帕金森病中氧化应激与调节性非编码RNA之间的相互作用仍有待阐明。在本文中，我们全面综述并概述了调节性非编码RNA与氧化应激在帕金森病中的作用。还总结了它们之间的相互作用。我们旨在为读者提供关于帕金森病发病机制的相对新颖的见解，这将有助于临床前诊断和治疗的发展。
