Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Int J Environ Res Public Health. 2021 Feb 1;18(3):1291. doi: 10.3390/ijerph18031291.
Cisplatin administration may induce muscle atrophy, thereby reducing the fitness level of patients with head and neck cancer (HNC). To date, only animal studies have been conducted to test the effectiveness of exercise interventions in diminishing side effects of cisplatin.
To determine whether exercise training improves physical fitness and health-related quality of life (HRQoL) in patients receiving chemotherapy for Head & Neck (H&N).
This pilot-randomized controlled trial was conducted on 57 participants receiving chemotherapy for HNC. The participants were randomized into an exercise group and a control group. The exercise group received moderate-intensity combined aerobic, resistance and flexibility exercises three times a week for eight weeks during chemotherapy. The control group received no specific information regarding exercise. The outcome measures including body composition, muscle strength, balance, flexibility, cardiovascular fitness and health-related quality of life (HRQoL) were assessed at baseline and eight weeks following baseline.
The body composition (body fat percentage, = 0.002; skeletal muscle percentage, = 0.008), dynamic balance ( = 0.01), muscle strength (upper extremity, = 0.037; lower extremity, = 0.025) and HRQoL ( = 0.001) showed a significant difference between the exercise group and the control group eight weeks following baseline. Significant deteriorations were noted in flexibility, muscle strength, cardiovascular fitness and several domains of HRQoL scale in the control group at eight weeks following baseline.
This study found that a combined aerobic, resistance and flexibility exercise program during chemotherapy may improve physical fitness (i.e., muscle strength, balance, flexibility and body composition) and HRQoL and alleviate the deterioration of cardiovascular fitness in patients with HNC. Further research studies with large sample sizes are warranted to investigate the long-term effects of exercise in this population.
顺铂给药可能会引起肌肉萎缩，从而降低头颈部癌症（HNC）患者的健康水平。迄今为止，仅进行了动物研究来测试运动干预在减轻顺铂副作用方面的效果。
确定运动训练是否能提高接受头颈部（H&N）化疗的患者的身体健康和健康相关生活质量（HRQoL）。
这是一项针对 57 名接受 HNC 化疗的患者的试点随机对照试验。参与者被随机分为运动组和对照组。运动组在化疗期间每周接受三次中等强度的有氧、阻力和柔韧性运动，共八周。对照组没有接受关于运动的具体信息。在基线和基线后八周评估身体成分、肌肉力量、平衡、柔韧性、心血管健康和健康相关生活质量（HRQoL）等结局指标。
身体成分（体脂肪百分比， = 0.002；骨骼肌百分比， = 0.008）、动态平衡（ = 0.01）、肌肉力量（上肢， = 0.037；下肢， = 0.025）和 HRQoL（ = 0.001）在基线后八周时，运动组与对照组之间存在显著差异。对照组在基线后八周时，柔韧性、肌肉力量、心血管健康和 HRQoL 量表的几个领域均显著恶化。
本研究发现，化疗期间进行有氧、阻力和柔韧性相结合的运动方案可能会提高身体健康（即肌肉力量、平衡、柔韧性和身体成分）和 HRQoL，并减轻 HNC 患者心血管健康的恶化。需要进一步进行大样本量的研究来研究该人群中运动的长期效果。
