Repka Chris P, Hayward Reid
1 Department of Health Sciences, Northern Arizona University, Flagstaff, AZ, USA.
2 Cancer Rehabilitation Institute, University of Northern Colorado, Greeley, CO, USA.
Integr Cancer Ther. 2018 Jun;17(2):503-510. doi: 10.1177/1534735418766402. Epub 2018 Apr 12.
Although the underlying mechanisms of cancer-related fatigue (CRF) are not fully characterized, treatment-associated oxidative stress may play a role. The purpose of this study was to determine the effect of an exercise intervention on the relationship between CRF and oxidative stress.
Upon cessation of radiation or chemotherapy, 8 cancer patients participated in a 10-week exercise intervention (EX), while 7 continued standard care (CON). Blood draws and fatigue questionnaires were administered to cancer patients before and after the intervention as well as to 7 age-matched individuals with no cancer history. Changes in plasma 8-hydroxy-deoxyguanosine (8-OHdG), protein carbonyls, antioxidant capacity, and fatigue were compared between groups. Correlations between CRF and oxidative stress were evaluated.
Mean total fatigue scores decreased significantly (5.0 ± 2.2 to 2.6 ± 1.5, P < .05) in EX, but not in CON. Antioxidant capacity significantly increased (+41%; P < .05) and protein carbonyls significantly decreased (-36%; P < .05) in EX, but not in CON. Increases in antioxidant capacity were significantly correlated with reductions in affective ( r = -.49), sensory ( r = -.47), and cognitive fatigue ( r = -.58). Changes in total ( r = .46) and affective ( r = .47) fatigue exhibited significant correlations with changes in 8-OHdG over time, while behavioral ( r = .46) and sensory ( r = .47) fatigue changes were significantly correlated with protein carbonyls.
Oxidative stress may be implicated in CRF, while improved antioxidant capacity following an exercise intervention may play a role in mitigating CRF in cancer survivors.
尽管癌症相关疲劳（CRF）的潜在机制尚未完全明确，但治疗相关的氧化应激可能起一定作用。本研究旨在确定运动干预对CRF与氧化应激之间关系的影响。
在放疗或化疗结束后，8名癌症患者参与了为期10周的运动干预（EX组），而7名患者继续接受标准护理（CON组）。在干预前后对癌症患者以及7名无癌症病史的年龄匹配个体进行血液抽取和疲劳问卷调查。比较两组之间血浆8-羟基脱氧鸟苷（8-OHdG）、蛋白质羰基、抗氧化能力和疲劳的变化。评估CRF与氧化应激之间的相关性。
EX组的平均总疲劳评分显著降低（从5.0±2.2降至2.6±1.5，P<.05），而CON组未降低。EX组的抗氧化能力显著增加（+41%；P<.05），蛋白质羰基显著降低（-36%；P<.05），而CON组未出现这些变化。抗氧化能力的增加与情感疲劳（r = -.49）、感觉疲劳（r = -.47）和认知疲劳（r = -.58）的降低显著相关。总疲劳（r =.46）和情感疲劳（r =.47）的变化与8-OHdG随时间的变化呈显著相关，而行为疲劳（r =.46）和感觉疲劳（r =.47）的变化与蛋白质羰基显著相关。
氧化应激可能与CRF有关，而运动干预后抗氧化能力的提高可能在减轻癌症幸存者的CRF中发挥作用。
