Barbu Madalina Gabriela, Thompson Richard James, Thompson Dana Claudia, Cretoiu Dragos, Suciu Nicolae
Alessandrescu-Rusescu National Institute for Mother and Child Health, Fetal Medicine Excellence Research Center, Bucharest, Romania.
Independent Researcher, Bucharest, Romania.
Front Med (Lausanne). 2020 Sep 9;7:567199. doi: 10.3389/fmed.2020.567199. eCollection 2020.
The SARS-CoV2 infection has rapidly spread throughout the world, particularly affecting those with underlying conditions. To assess the impact of SARS-CoV-2 on the most prevalent comorbidities, among people who died of COVID-19 in Romania. The study comprised 814 deaths caused by COVID-19 between 22nd March and 8th May, 2020 as reported by the Ministry of Health. WHO data regarding deaths of the general population of Romania was used for comparison. The study analyzed the demographics, number and prevalence of comorbidities and calculated the relative risk for each comorbidity. The study sample consisted of 61.4% males and 38.6% females; the mean age was 68.2 y; 90.9% of deaths occurred in people 50+ years. The mean number of pre-existing conditions was 2.73 (SD = 1.521), with 97.4% of the patients having at least one. The most prevalent comorbidities were hypertension (43.1%), diabetes (33.2%), and coronary heart disease (26.0%). The calculated relative risk of death due to COVID-19 was divided into 3 risk categories: high impact comorbidities (RR > 3) included diabetes RR = 6.426 (95% CI, 4.965-8.318), chronic renal disease RR = 4.338 (95% CI, 3.556-5.292) and hypertension RR=3.261 (95% CI, 2.687-3.958). The medium impact (RR = 2-3) group comprised chronic pulmonary disease RR = 2.615 (95% CI, 2.061-3.319) and chronic liver disease RR = 1.577 (95% CI, 1.183-2.104) and the low impact group (RR<2) -coronary heart disease RR = 0.664 (95% CI, 0.581-0.758), cancer RR = 0.515 (95% CI, 0.416-0.637) and stroke RR = 0.468 (95% CI, 0.370-0.593). In the studied sample, SARS-CoV-2 had a greater impact on people with diabetes, chronic renal disease and hypertension and a lesser impact on those with coronary heart disease, cancer and stroke. Therefore, future policies in Romania should focus on shielding people in the high-risk group and prioritizing them for vaccination, whilst encouraging those in the low risk group to continue seeking treatment for their underlying diseases.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染已在全球迅速传播，尤其对有基础疾病的人群影响较大。为评估SARS-CoV-2对罗马尼亚新冠肺炎死亡病例中最常见合并症的影响。该研究纳入了2020年3月22日至5月8日期间卫生部报告的814例新冠肺炎死亡病例。使用世界卫生组织关于罗马尼亚普通人群死亡的数据进行比较。该研究分析了人口统计学特征、合并症的数量和患病率，并计算了每种合并症的相对风险。研究样本中男性占61.4%，女性占38.6%；平均年龄为68.2岁；90.9%的死亡病例发生在50岁及以上人群。既往存在的疾病平均数量为2.73种（标准差=1.521），97.4%的患者至少有一种。最常见的合并症为高血压（43.1%）、糖尿病（33.2%）和冠心病（26.0%）。计算得出的新冠肺炎死亡相对风险分为3个风险类别：高影响合并症（相对风险>3）包括糖尿病，相对风险=6.426（95%置信区间，4.965-8.318），慢性肾病，相对风险=4.338（95%置信区间，3.556-5.292），高血压，相对风险=3.261（95%置信区间，2.687-3.958）。中等影响（相对风险=2-3）组包括慢性肺病，相对风险=2.615（95%置信区间，2.061-3.319）和慢性肝病，相对风险=1.577（95%置信区间，1.183-2.104），低影响组（相对风险<2）——冠心病，相对风险=0.664（95%置信区间，0.581-0.758），癌症，相对风险=0.515（95%置信区间，0.416-
