Lenoir Alexandra, Fuertes Elaine, Gómez-Real Francisco, Leynaert Benedicte, van der Plaat Diana A, Jarvis Debbie
National Heart and Lung Institute, Imperial College London, London, UK.
Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
ERJ Open Res. 2020 Sep 28;6(3). doi: 10.1183/23120541.00070-2020. eCollection 2020 Jul.
Higher levels of testosterone have been associated with better lung function in cross-sectional population-based studies. The role of testosterone in lung function in women and in lung function decline in men or women is unclear. We studied 5114 men and 5467 women in the UK Biobank with high-quality spirometry at baseline (2006-2010) and 8.4 years later. We studied cross-sectional associations of total testosterone (TT), calculated free testosterone (cFT), free androgen index (FAI) and sex hormone-binding globulin (SHBG) with forced expiratory volume in 1 s (FEV), forced vital capacity (FVC) and FEV/FVC using linear regression and associations of baseline markers with lung function decline using linear mixed-effects regression. Men with higher levels of TT had higher FEV (27.56 mL per interquartile range increase TT, 95% CI 5.43-49.68) and FVC (48.06 mL, 95% CI 22.07-74.06) at baseline. Higher cFT levels were associated with higher FEV and FVC among physically active men only. In women, higher FAI and cFT levels were associated with lower lung function at baseline and higher levels of TT, cFT and FAI were associated with slightly attenuated FEV and FVC decline. Higher levels of SHBG were associated with better lung function in both sexes but slightly accelerated decline in men. In this population-based sample, higher levels of TT were associated with better lung function in men and higher levels of cFT with better lung function in physically active men. A small attenuation of lung function decline with higher levels of TT, cFT and FAI was seen in women only.
在基于人群的横断面研究中，较高水平的睾酮与更好的肺功能相关。睾酮在女性肺功能以及男性或女性肺功能下降中的作用尚不清楚。我们在英国生物银行中研究了5114名男性和5467名女性，这些人在基线时（2006 - 2010年）以及8.4年后进行了高质量的肺活量测定。我们使用线性回归研究了总睾酮（TT）、计算游离睾酮（cFT）、游离雄激素指数（FAI）和性激素结合球蛋白（SHBG）与第1秒用力呼气量（FEV）、用力肺活量（FVC）和FEV/FVC的横断面关联，并使用线性混合效应回归研究了基线指标与肺功能下降的关联。基线时，TT水平较高的男性FEV（每四分位数间距增加TT，FEV增加27.56 mL，95%可信区间5.43 - 49.68）和FVC（48.06 mL，95%可信区间22.07 - 74.06）较高。仅在身体活跃的男性中，较高的cFT水平与较高的FEV和FVC相关。在女性中，较高的FAI和cFT水平与基线时较低的肺功能相关，而较高水平的TT、cFT和FAI与FEV和FVC下降略有减弱相关。较高水平的SHBG与两性更好的肺功能相关，但与男性肺功能下降略有加速相关。在这个基于人群的样本中，较高水平的TT与男性更好的肺功能相关，较高水平的cFT与身体活跃男性更好的肺功能相关。仅在女性中观察到较高水平的TT、cFT和FAI使肺功能下降略有减弱。
