Research Center for Plant Functional Components, Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao, China.
Graduate School, Chinese Academy of Agricultural Sciences, Beijing, China.
Nat Prod Res. 2021 Dec;35(24):6134-6140. doi: 10.1080/14786419.2020.1828410. Epub 2020 Oct 4.
One new xanthone, chryxanthone C (), together with four known analogues (-), were isolated from the cultures of sp. TE-540, an endophytic fungus obtained from the leaves of L. The structure of was elucidated by comprehensive spectral analysis including HRESIMS and 1D/2D NMR, which were confirmed by Cu Kα X-ray crystallography. Compound featured an unusual dihydropyran ring fused to an aromatic ring, rather than the commonly occurring prenyl moiety. The cytotoxicity of compounds - were evaluated against five human tumour cell lines and exhibited moderate to strong cytotoxicities with IC values ranging from 5.6 to 14.2 µM.
从内生真菌 sp. TE-540 的培养物中分离得到一种新的呫吨酮 Chryxanthone C ()，以及四种已知类似物 (-)。通过包括高分辨率电喷雾质谱 (HRESIMS) 和 1D/2D NMR 在内的综合光谱分析阐明了 的结构，并通过 Cu Kα X 射线晶体学得到了证实。化合物 具有不常见的二氢吡喃环与芳环融合，而不是常见的异戊烯部分。化合物 - 对五种人肿瘤细胞系的细胞毒性进行了评价，结果表明 表现出中等至较强的细胞毒性，IC 值范围为 5.6 至 14.2 μM。
