Cytotoxic xanthones from the plant endophytic fungus sp. TE-540.

One new xanthone, chryxanthone C (), together with four known analogues (-), were isolated from the cultures of sp. TE-540, an endophytic fungus obtained from the leaves of L. The structure of was elucidated by comprehensive spectral analysis including HRESIMS and 1D/2D NMR, which were confirmed by Cu Kα X-ray crystallography. Compound featured an unusual dihydropyran ring fused to an aromatic ring, rather than the commonly occurring prenyl moiety. The cytotoxicity of compounds - were evaluated against five human tumour cell lines and exhibited moderate to strong cytotoxicities with IC values ranging from 5.6 to 14.2 µM.