Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, GA, The Netherlands.
Epigenetics. 2021 Aug;16(8):838-850. doi: 10.1080/15592294.2020.1827723. Epub 2020 Oct 4.
Acetylation of histone and non-histone proteins is a post-translational modification mostly associated with activation of gene transcription. The first histone acetyltransferase (HAT) identified as modifying newly synthesized histone H4 in yeast was a type B HAT named . Although it was the first HAT to be discovered, HAT1 remains one of the most poorly studied enzymes in its class. In addition to its well-established role in the cytoplasm, recent findings have revealed new and intriguing aspects of the function of HAT1 in the nucleus. Several studies have described its involvement in regulating different pathways associated with a wide range of diseases, including cancer. This review focuses on our current understanding of , highlighting its importance in regulating chromatin replication and gene expression. This previously unknown role for opens up novel scenarios in which further studies will be required to better understand its function.
组蛋白和非组蛋白的乙酰化是一种翻译后修饰，主要与基因转录的激活有关。在酵母中被鉴定为修饰新合成的组蛋白 H4 的第一个组蛋白乙酰转移酶 (HAT) 是一种 B 型 HAT，称为. 虽然它是第一个被发现的 HAT，但 HAT1 仍然是其同类中研究最少的酶之一。除了其在细胞质中已确立的作用外，最近的发现揭示了 HAT1 在核内的功能的新的、有趣的方面。几项研究描述了它参与调节与广泛的疾病（包括癌症）相关的不同途径。本文综述了我们目前对 的理解，强调了它在调节染色质复制和基因表达中的重要性。 这个以前未知的作用 为进一步研究其功能开辟了新的场景。
