Sohn Won J, Wang Po T, Kellis Spencer, Andersen Richard A, Liu Charles Y, Heydari Payam, Nenadic Zoran, Do An H
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:3083-3085. doi: 10.1109/EMBC44109.2020.9176718.
Bi-directional brain-computer interfaces (BD-BCI) to restore movement and sensation must achieve concurrent operation of recording and decoding of motor commands from the brain and stimulating the brain with somatosensory feedback. Previously we developed and validated a benchtop prototype of a fully implantable BCI system for motor decoding. Here, a prototype artificial sensory stimulator was integrated into the benchtop system to develop a prototype of a fully-implantable BD-BCI. The artificial sensory stimulator incorporates an active charge balancing mechanism based on pulse-width modulation to ensure safe stimulation for chronically interfaced electrodes to prevent damage to brain tissue and electrodes. The feasibility of the BD-BCI system's active charge balancing was tested in phantom brain tissue. With the charge-balancing, the removal of the residual charges on an electrode was evident. This is a critical milestone toward fully-implantable BD-BCI systems.
用于恢复运动和感觉的双向脑机接口（BD-BCI）必须实现从大脑记录和解码运动指令以及通过体感反馈刺激大脑的并发操作。此前我们开发并验证了一种用于运动解码的完全可植入BCI系统的台式原型。在此，将一个原型人工感觉刺激器集成到台式系统中，以开发一种完全可植入BD-BCI的原型。该人工感觉刺激器采用基于脉宽调制的有源电荷平衡机制，以确保对长期连接的电极进行安全刺激，防止对脑组织和电极造成损伤。在虚拟脑组织中测试了BD-BCI系统有源电荷平衡的可行性。通过电荷平衡，电极上残余电荷的去除很明显。这是朝着完全可植入BD-BCI系统迈出的关键一步。
