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抗阻训练和乙醇提取物对周围神经损伤大鼠氧化应激标志物的影响。

Effects of Resistance Training and Hydroethanolic Extract on Oxidative Stress Markers in Rats Submitted to Peripheral Nerve Injury.

作者信息

Costa Luana Santos, Aidar Felipe J, Matos Dihogo Gama de, Oliveira José Uilien de, Santos Jymmys Lopes Dos, Almeida-Neto Paulo Francisco de, Souza Raphael Fabrício de, Pereira Danielle Dutra, Garrido Nuno Domingos, Nunes-Silva Albená, Marçal Anderson Carlos, Estevam Charles Dos Santos, Cabral Breno Guilherme de Araújo Tinoco, Reis Victor Machado, Teixeira Mauro Martins

机构信息

Program of Physiological Science, Federal University of Sergipe (UFS), São Cristovão 49100-000, Sergipe, Brazil.

Group of Studies and Research of Performance, Sport, Health and Paralympic Sports (GEPEPS), Federal University of Sergipe (UFS), São Cristovão 49100-000, Sergipe, Brazil.

出版信息

Antioxidants (Basel). 2020 Oct 1;9(10):941. doi: 10.3390/antiox9100941.

DOI:10.3390/antiox9100941
PMID:33019503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7601135/
Abstract

The objective of this study was to analyze the effects of the combination of resistance training (RT) and the hydroethanolic extract (EHE) of as markers of oxidative stress (OS) in rats with peripheral nerve injury (PNI). Rats were allocated into six groups ( = 10): animals without interventions (C), animals with an exposed nerve but without injury, injured animals, trained and injured animals, injured animals that received EHE, and animals that received a combination of RT and EHE. RT comprised the climbing of stairs. EHE was orally administered (200 mg/kg) for 21 days after PNI induction. RT reduced the amount of lipoperoxidation in plasma (14.11%). EHE reduced lipoperoxidation in the plasma (20.72%) and the brain (41.36). RT associated with the extract simultaneously reduced lipoperoxidation in the plasma (34.23%), muscle (25.13%), and brain (43.98%). There was an increase in total sulhydrilyl levels (a) in the brain (33.33%) via RT; (b) in the brain (44.44%) and muscle (44.51%) using EHE; and (c) in the plasma (54.02%), brain (54.25%), and muscle using the combination of RT + EHE. These results suggest that RT associated with oral EHE results in a decrease in OS.

摘要

本研究的目的是分析抗阻训练（RT）与[植物名称]水乙醇提取物（EHE）联合使用对周围神经损伤（PNI）大鼠氧化应激（OS）标志物的影响。将大鼠分为六组（每组n = 10）：未干预的动物（C组）、神经暴露但未受伤的动物、受伤动物、训练且受伤的动物、接受EHE的受伤动物以及接受RT与EHE联合治疗的动物。RT包括爬楼梯。在诱导PNI后，口服给予EHE（200 mg/kg），持续21天。RT使血浆中脂质过氧化量降低（14.11%）。EHE使血浆中脂质过氧化降低（20.72%），使大脑中脂质过氧化降低（41.36%）。RT与提取物联合使用同时使血浆（34.23%）、肌肉（25.13%）和大脑（43.98%）中的脂质过氧化降低。通过RT，大脑中总巯基水平升高（a）（33.33%）；使用EHE，大脑（44.44%）和肌肉（44.51%）中总巯基水平升高；使用RT + EHE联合治疗，血浆（54.02%）、大脑（54.25%）和肌肉中总巯基水平升高。这些结果表明，RT与口服EHE联合使用可降低OS。

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