Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Curr Biol. 2020 Oct 5;30(19):R1163-R1169. doi: 10.1016/j.cub.2020.07.032.
Fungi are key components in global biogeochemical cycles, play important roles in manufacturing industries and biomedical research, and influence humans through their impact on global health, agriculture, and biodiversity. Fungi have been isolated from almost every environmental niche across the planet, including from air, soil, fresh water, and the oceans. Although the vast majority of fungi do not exhibit pathogenic traits, some species cause infections in humans ranging from superficial to life-threatening. Moreover, some fungal species are plant pathogens and have devastating impacts on agriculture. In this primer, we aim to provide a broad picture of what makes fungal pathogens unique, as well as the challenges of combating fungal pathogens.
真菌是全球生物地球化学循环的关键组成部分，在制造业和生物医药研究中发挥着重要作用，并通过其对全球健康、农业和生物多样性的影响而作用于人类。真菌几乎存在于地球的每一个环境小生境中，包括空气、土壤、淡水和海洋。虽然绝大多数真菌不表现出致病特性，但有些物种会导致人类从浅表到危及生命的感染。此外，一些真菌物种是植物病原体，对农业造成了毁灭性的影响。在这篇入门文章中，我们旨在提供一幅广泛的画面，说明是什么使真菌病原体具有独特性，以及对抗真菌病原体的挑战。
