Potter Matthew L, Hill William D, Isales Carlos M, Hamrick Mark W, Fulzele Sadanand
Department of Orthopedics, Augusta University, Augusta, GA, United States of America.
Medical University of South Carolina, Charleston, SC 29403, United States of America; Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC, 29403, United States of America.
Bone. 2021 Jan;142:115679. doi: 10.1016/j.bone.2020.115679. Epub 2020 Oct 3.
MicroRNAs (miRNAs) have recently come under scrutiny for their role in various age-related diseases. Similarly, cellular senescence has been linked to disease and aging. MicroRNAs and senescence likely play an intertwined role in driving these pathologic states. In this review, we present the connection between these two drivers of age-related disease concerning mesenchymal stem cells (MSCs). First, we summarize key miRNAs that are differentially expressed in MSCs and other musculoskeletal lineage cells during senescence and aging. Additionally, we also reviewed miRNAs that are regulated via traditional senescence-associated secretory phenotype (SASP) cytokines in MSC. Lastly, we summarize miRNAs that have been found to target components of the cell cycle arrest pathways inherently activated in senescence. This review attempts to highlight potential miRNA targets for regenerative medicine applications in age-related musculoskeletal disease.
微小RNA（miRNA）最近因其在各种与年龄相关疾病中的作用而受到关注。同样，细胞衰老也与疾病和衰老有关。微小RNA和衰老可能在驱动这些病理状态中发挥相互交织的作用。在本综述中，我们阐述了与间充质干细胞（MSC）相关的这两种与年龄相关疾病驱动因素之间的联系。首先，我们总结了在衰老和老化过程中，MSC及其他肌肉骨骼谱系细胞中差异表达的关键miRNA。此外，我们还综述了通过传统衰老相关分泌表型（SASP）细胞因子在MSC中调控的miRNA。最后，我们总结了已发现靶向衰老过程中固有激活的细胞周期停滞途径成分的miRNA。本综述试图突出在与年龄相关的肌肉骨骼疾病中再生医学应用的潜在miRNA靶点。
