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MicroRNAs are critical regulators of senescence and aging in mesenchymal stem cells.微小RNA是间充质干细胞衰老过程中的关键调节因子。
Bone. 2021 Jan;142:115679. doi: 10.1016/j.bone.2020.115679. Epub 2020 Oct 3.
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Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway.微小 RNA 调控代谢综合征诱导的猪脂肪组织来源间充质干细胞衰老通过 P16/MAPK 通路。
Cell Transplant. 2018 Oct;27(10):1495-1503. doi: 10.1177/0963689718795692. Epub 2018 Sep 6.
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Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src.间充质干细胞来源的小细胞外囊泡通过调节 miR-146a/Src 减轻内皮细胞氧化应激诱导的衰老。
Signal Transduct Target Ther. 2021 Oct 22;6(1):354. doi: 10.1038/s41392-021-00765-3.
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miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53-p21 and p16-pRB pathways.微小RNA-29c-3p通过p53-p21和p16-pRB途径靶向CNOT6促进人间充质干细胞衰老。
Biochim Biophys Acta. 2016 Apr;1863(4):520-32. doi: 10.1016/j.bbamcr.2016.01.005. Epub 2016 Jan 11.
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Quantifying Senescence-Associated Phenotypes in Primary Multipotent Mesenchymal Stromal Cell Cultures.定量原代多能间充质基质细胞培养物中的衰老相关表型。
Methods Mol Biol. 2019;2045:93-105. doi: 10.1007/7651_2019_217.
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Ageing and mesenchymal stem cells derived exosomes: Molecular insight and challenges.衰老与间充质干细胞衍生的外泌体：分子机制与挑战
Cell Biochem Funct. 2021 Jan;39(1):60-66. doi: 10.1002/cbf.3602. Epub 2020 Nov 8.
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Senotherapeutics for mesenchymal stem cell senescence and rejuvenation.用于间充质干细胞衰老与年轻化的衰老疗法。
Drug Discov Today. 2023 Jan;28(1):103424. doi: 10.1016/j.drudis.2022.103424. Epub 2022 Nov 1.
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Fisetin Attenuates Cellular Senescence Accumulation During Culture Expansion of Human Adipose-Derived Stem Cells.金雀异黄素可减轻人脂肪来源干细胞体外培养扩增过程中的细胞衰老积累。
Stem Cells. 2023 Jul 14;41(7):698-710. doi: 10.1093/stmcls/sxad036.
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Tackling cellular senescence by targeting miRNAs.靶向 microRNAs 治疗细胞衰老。
Biogerontology. 2022 Aug;23(4):387-400. doi: 10.1007/s10522-022-09972-z. Epub 2022 Jun 21.
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Microvesicles as Potential Biomarkers for the Identification of Senescence in Human Mesenchymal Stem Cells.微泡作为鉴定人骨髓间充质干细胞衰老的潜在生物标志物
Theranostics. 2017 Jul 6;7(10):2673-2689. doi: 10.7150/thno.18915. eCollection 2017.
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Extracellular Vesicles of Adipose Multipotent Mesenchymal Stromal Cells Propagate Senescent Phenotype by Affecting PTEN Nuclear Import.脂肪多能间充质基质细胞的细胞外囊泡通过影响PTEN核输入来传播衰老表型。
Int J Mol Sci. 2025 Jul 24;26(15):7164. doi: 10.3390/ijms26157164.
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Mechanisms and therapeutic strategies linking mesenchymal stem cells senescence to osteoporosis.将间充质干细胞衰老与骨质疏松症联系起来的机制及治疗策略。
Front Endocrinol (Lausanne). 2025 Jul 21;16:1625806. doi: 10.3389/fendo.2025.1625806. eCollection 2025.
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Cellular senescence, neuroinflammation, and microRNAs: Possible interactions driving aging and neurodegeneration in the hippocampal neurogenic niche.细胞衰老、神经炎症与微小RNA：驱动海马神经发生微环境衰老和神经退行性变的可能相互作用
Aging Brain. 2025 Jun 12;8:100141. doi: 10.1016/j.nbas.2025.100141. eCollection 2025.
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Emerging insights in senescence: pathways from preclinical models to therapeutic innovations.衰老领域的新见解：从临床前模型到治疗创新的途径
NPJ Aging. 2024 Nov 22;10(1):53. doi: 10.1038/s41514-024-00181-1.
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Engineering mesenchymal stem cells for premature ovarian failure: overcoming challenges and innovating therapeutic strategies.工程间充质干细胞治疗卵巢早衰：克服挑战和创新治疗策略。
Theranostics. 2024 Oct 7;14(17):6487-6515. doi: 10.7150/thno.102641. eCollection 2024.
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Effects of Replicative Senescence of Human Chorionic MSCs on their EV-miRNA Profile.人绒毛膜间充质干细胞复制性衰老对其 EV-miRNA 谱的影响。
Stem Cell Rev Rep. 2024 Nov;20(8):2318-2335. doi: 10.1007/s12015-024-10790-8. Epub 2024 Sep 21.
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Genetic and Epigenetic Interactions Involved in Senescence of Stem Cells.遗传和表观遗传相互作用在干细胞衰老中的作用。
Int J Mol Sci. 2024 Sep 7;25(17):9708. doi: 10.3390/ijms25179708.
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SCD2 Regulation Targeted by miR-200c-3p on Lipogenesis Alleviates Mesenchymal Stromal Cell Senescence.miR-200c-3p 靶向调控 SCD2 对脂肪生成的抑制作用减轻间充质基质细胞衰老。
Int J Mol Sci. 2024 Aug 5;25(15):8538. doi: 10.3390/ijms25158538.
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MicroRNA-18a prevents senescence of mesenchymal stem cells by targeting CTDSPL.MicroRNA-18a 通过靶向 CTDSPL 防止间充质干细胞衰老。
Aging (Albany NY). 2024 Mar 7;16(5):4904-4919. doi: 10.18632/aging.205642.
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MiR-145-5p overexpression rejuvenates aged adipose stem cells and accelerates wound healing.miR-145-5p 过表达可恢复衰老脂肪干细胞活力并加速伤口愈合。
Biol Open. 2024 Feb 15;13(2). doi: 10.1242/bio.060117. Epub 2024 Feb 19.
本文引用的文献
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The protective effects of microRNA-26a in steroid-induced osteonecrosis of the femoral head by repressing EZH2.微小RNA-26a通过抑制EZH2对激素性股骨头坏死的保护作用
Cell Cycle. 2020 Mar;19(5):551-566. doi: 10.1080/15384101.2020.1717043. Epub 2020 Feb 13.
2
A proteomic atlas of senescence-associated secretomes for aging biomarker development.衰老相关分泌表型的蛋白质组学图谱用于衰老生物标志物的开发。
PLoS Biol. 2020 Jan 16;18(1):e3000599. doi: 10.1371/journal.pbio.3000599. eCollection 2020 Jan.
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Cellular Senescence: Defining a Path Forward.细胞衰老：定义前进的道路。
Cell. 2019 Oct 31;179(4):813-827. doi: 10.1016/j.cell.2019.10.005.
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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.衰老细胞清除剂可减少人类的衰老细胞：达沙替尼联合槲皮素治疗糖尿病肾病患者的临床试验初步报告。
EBioMedicine. 2019 Sep;47:446-456. doi: 10.1016/j.ebiom.2019.08.069. Epub 2019 Sep 18.
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MicroRNA-141-3p Negatively Modulates SDF-1 Expression in Age-Dependent Pathophysiology of Human and Murine Bone Marrow Stromal Cells.微小 RNA-141-3p 负调控人源和鼠源骨髓基质细胞衰老相关病理生理学中 SDF-1 的表达。
J Gerontol A Biol Sci Med Sci. 2019 Aug 16;74(9):1368-1374. doi: 10.1093/gerona/gly186.
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How close are miRNAs from clinical practice? A perspective on the diagnostic and therapeutic market.微小RNA（miRNA）距离临床应用还有多远？关于诊断和治疗市场的展望。
EJIFCC. 2019 Jun 24;30(2):114-127. eCollection 2019 Jun.
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miR‑767‑5p inhibits glioma proliferation and metastasis by targeting SUZ12.miR-767-5p 通过靶向 SUZ12 抑制神经胶质瘤的增殖和转移。
Oncol Rep. 2019 Jul;42(1):55-66. doi: 10.3892/or.2019.7156. Epub 2019 May 13.
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Senescence Signature in Skin Biopsies From Systemic Sclerosis Patients Treated With Senolytic Therapy: Potential Predictor of Clinical Response?接受衰老细胞清除疗法的系统性硬化症患者皮肤活检中的衰老特征：临床反应的潜在预测指标？
Arthritis Rheumatol. 2019 Oct;71(10):1766-1767. doi: 10.1002/art.40934. Epub 2019 Sep 2.
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Senescent cell clearance by the immune system: Emerging therapeutic opportunities.免疫系统清除衰老细胞：新的治疗机会。
Semin Immunol. 2018 Dec;40:101275. doi: 10.1016/j.smim.2019.04.003. Epub 2019 May 11.
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Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development.应激激活的 miR-204 调控软骨细胞衰老表型促进骨关节炎发生发展。
Sci Transl Med. 2019 Apr 3;11(486). doi: 10.1126/scitranslmed.aar6659.
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