Jung Ju-Yeon, Park Chan-A, Lee Yeong-Bae, Kang Chang-Ki
Department of Health Science, Gachon University Graduate School, Incheon 21936, Korea.
Biomedical Engineering Research Center, Gachon University, Incheon 21936, Korea.
Brain Sci. 2020 Oct 3;10(10):704. doi: 10.3390/brainsci10100704.
The problems of mouth breathing have been well-studied, but the neural correlates of functional connectivity (FC) still remain unclear. We examined the difference in FC between the two types of breathing. For our study, 21 healthy subjects performed voluntary mouth and nasal breathing conditions during a resting state functional magnetic resonance imaging (fMRI). The region of interest (ROI) analysis of FC in fMRI was conducted using a MATLAB-based imaging software. The resulting analysis showed that mouth breathing had widespread connections and more left lateralization. Left inferior temporal gyrus had the most left lateralized connections in mouth breathing condition. Furthermore, the central opercular cortex FC showed a significant relationship with mouth breathing. For nasal breathing, the sensorimotor area had symmetry FC pattern. These findings suggest that various FCs difference appeared between two breathing conditions. The impacts of these differences need to be more investigated to find out potential link with cognitive decline in mouth breathing syndrome.
口呼吸问题已得到充分研究，但功能连接（FC）的神经关联仍不明确。我们研究了两种呼吸方式下FC的差异。在本研究中，21名健康受试者在静息态功能磁共振成像（fMRI）期间进行了自主口呼吸和鼻呼吸。使用基于MATLAB的成像软件对fMRI中的FC进行感兴趣区域（ROI）分析。结果分析表明，口呼吸具有广泛的连接且更多地偏向左侧化。在口呼吸状态下，左下颞回具有最偏向左侧的连接。此外，中央 opercular 皮层FC与口呼吸呈显著相关。对于鼻呼吸，感觉运动区具有对称的FC模式。这些发现表明，两种呼吸状态之间出现了各种FC差异。需要进一步研究这些差异的影响，以找出与口呼吸综合征认知衰退的潜在联系。
