Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan.
Student Counseling Center, National Defense Medical Center, Taipei, Taiwan.
Transl Psychiatry. 2020 Oct 6;10(1):339. doi: 10.1038/s41398-020-01021-y.
There were several studies about the psychiatric and mental health issues related to the severe adult respiratory syndrome (SARS) outbreak in 2003, however, the association between SARS and the overall risk of psychiatric disorders and suicides has, as yet, to be studied in Taiwan. The aim of this study is to examine as to whether SARS is associated with the risk of psychiatric disorders and suicide. A total of 285 patients with SARS and 2850 controls without SARS (1:10) matched for sex, age, insurance premium, comorbidities, residential regions, level of medical care, and index date were selected between February 25 and June 15, 2003 from the Inpatient Database Taiwan's National Health Insurance Research Database. During the 12-year follow-up, in which 79 in the SARS cohort and 340 in the control group developed psychiatric disorders or suicide (4047.41 vs. 1535.32 per 100,000 person-years). Fine and Gray's survival analysis revealed that the SARS cohort was associated with an increased risk of psychiatric disorders and suicide, and the adjusted subdistribution HR (sHR) was 2.805 (95% CI: 2.182-3.605, p < 0.001) for psychiatric disorders and suicide. The SARS cohort was associated with anxiety, depression, sleep disorders, posttraumatic stress disorder/acute stress disorder (PTSD/ASD), and suicide. The sensitivity analysis revealed that the SARS group was associated with anxiety, depression, sleep disorders, PTSD/ASD, and suicide after the individuals with a diagnosis of psychiatric disorders and suicide were excluded within the first year, and with anxiety, depression, and sleep disorders, while those in the first five years were excluded. In conclusion, SARS was associated with the increased risk of psychiatric disorders and suicide.
2003 年严重急性呼吸系统综合征（SARS）爆发后，有几项关于精神和心理健康问题的研究，但 SARS 与精神障碍和自杀总体风险之间的关联尚未在台湾进行研究。本研究旨在探讨 SARS 是否与精神障碍和自杀风险相关。我们于 2003 年 2 月 25 日至 6 月 15 日从台湾全民健康保险研究数据库的住院患者数据库中，选择了 285 例 SARS 患者和 2850 例非 SARS 对照者（1:10），按性别、年龄、保险费、合并症、居住地区、医疗水平和索引日期进行匹配。在 12 年的随访期间，SARS 队列中有 79 例和对照组中有 340 例发生精神障碍或自杀（4047.41 比 1535.32/100000 人年）。Fine 和 Gray 的生存分析显示，SARS 队列与精神障碍和自杀风险增加相关，调整后的亚分布风险比（sHR）为 2.805（95%CI：2.182-3.605，p<0.001）。SARS 队列与焦虑、抑郁、睡眠障碍、创伤后应激障碍/急性应激障碍（PTSD/ASD）和自杀有关。敏感性分析显示，在排除第一年诊断为精神障碍和自杀的个体后，SARS 组与焦虑、抑郁、睡眠障碍、PTSD/ASD 和自杀相关，在前五年排除后与焦虑、抑郁和睡眠障碍相关。总之，SARS 与精神障碍和自杀风险增加有关。
