血清维生素 D 与波多黎各裔波士顿地区人群抑郁症状之间的关系
Serum Vitamin D and Depressive Symptomatology among Boston-Area Puerto Ricans.
机构信息
Department of Public Health, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, Lowell, MA, USA.
Department of Mathematical Sciences, University of Massachusetts Lowell, Lowell, MA, USA.
出版信息
J Nutr. 2020 Dec 10;150(12):3231-3240. doi: 10.1093/jn/nxaa253.
BACKGROUND
Low vitamin D status, assessed using serum 25-hydroxyvitamin D [25(OH)D] concentration, has been associated with depression, but research among minority populations, such as Puerto Ricans is limited. We examined the association between serum 25(OH)D and self-reported depressive symptomatology across 3 waves of follow-up in a cohort of Puerto Rican adults residing in Massachusetts.
OBJECTIVES
We evaluated the cross-sectional and longitudinal associations between serum 25(OH)D and self-reported depressive symptoms in the Boston Puerto Rican Health Study (BPRHS) cohort.
METHODS
Participants of the BPRHS were evaluated for depressive symptoms using the Center for Epidemiologic Studies Depression Scale (CES-D). Serum 25(OH)D was measured at baseline (n = 1434), year 2 (n = 1218), and year 5 (n = 914). We categorized serum 25(OH)D concentration as sufficient (≥20 ng/mL), insufficient (12 to <20 ng/mL), and deficient (<12 ng/mL). Multivariable linear regression was used for cross-sectional analyses at baseline, and repeated measures mixed effects modeling was used over 3 waves of follow-up for longitudinal analyses. We conducted sensitivity analyses in vitamin D supplement nonusers and participants with complete data on baseline serum 25(OH)D and CES-D at all 3 visits.
RESULTS
Serum 25(OH)D concentration was not associated with CES-D score in cross-sectional analysis [β = -0.85; 95% CI: -2.80, 1.10 for deficient compared with sufficient 25(OH)D; P-trend = 0.59] or in longitudinal analyses over 5 y [β = -0.41; 95% CI: -1.95, 1.13 for deficient compared with sufficient 25(OH)D; P-trend = 0.93]. Results were similar in sensitivity analyses restricted to vitamin D supplement nonusers (n = 1371) and in analyses conducted in participants with complete measures of baseline serum 25(OH)D and CES-D score at all 3 visits (n = 887) [β = -0.12; 95% CI: -1.98, 1.74 for deficient compared with sufficient 25(OH)D; P-trend = 0.93].
CONCLUSIONS
We did not observe a significant association between serum 25(OH)D and depressive symptomatology in the BPRHS cohort.
背景
使用血清 25-羟维生素 D [25(OH)D] 浓度评估的维生素 D 状态较低与抑郁症有关，但针对波多黎各等少数族裔人群的研究有限。我们在马萨诸塞州居住的波多黎各成年人队列中，通过 3 次随访检查了血清 25(OH)D 与自我报告的抑郁症状之间的关联。
目的
我们评估了波士顿波多黎各健康研究（BPRHS）队列中血清 25(OH)D 与自我报告的抑郁症状之间的横断面和纵向关联。
方法
使用流行病学研究中心抑郁量表（CES-D）评估 BPRHS 参与者的抑郁症状。在基线（n=1434）、第 2 年（n=1218）和第 5 年（n=914）测量血清 25(OH)D。我们将血清 25(OH)D 浓度分类为充足（≥20ng/mL）、不足（12 至<20ng/mL）和缺乏（<12ng/mL）。在基线的横断面分析中使用多变量线性回归，在 3 次随访的重复测量混合效应模型中进行纵向分析。我们在维生素 D 补充剂非使用者和在所有 3 次就诊时均具有完整基线血清 25(OH)D 和 CES-D 数据的参与者中进行了敏感性分析。
结果
在横断面分析中，血清 25(OH)D 浓度与 CES-D 评分无关[β=-0.85；与充足 25(OH)D 相比，缺乏的 25(OH)D 的 95%CI：-2.80，1.10；P 趋势=0.59]或在 5 年的纵向分析中[β=-0.41；与充足 25(OH)D 相比，缺乏的 25(OH)D 的 95%CI：-1.95，1.13；P 趋势=0.93]。在仅包括维生素 D 补充剂非使用者（n=1371）的敏感性分析中以及在所有 3 次就诊时均具有完整的基线血清 25(OH)D 和 CES-D 评分的参与者（n=887）的分析中，结果相似[β=-0.12；与充足 25(OH)D 相比，缺乏的 25(OH)D 的 95%CI：-1.98，1.74；P 趋势=0.93]。
结论
我们在 BPRHS 队列中未观察到血清 25(OH)D 与抑郁症状之间存在显著关联。
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