Middlekauff Holly R, William Kevin J, Su Baolong, Haptonstall Kacey, Araujo Jesus A, Wu Xiaohui, Kim Jason, Sallam Tamer
Division of Cardiology, Department of Medicine, University of California, Los Angeles, CA, USA.
Molecular, Cellular and Integrative Physiology Program, University of California, Los Angeles, CA, USA.
J Transl Med. 2020 Oct 7;18(1):379. doi: 10.1186/s12967-020-02557-9.
Electronic cigarette use is on the rise despite a number of reports linking electronic cigarettes with adverse health outcomes. Recent studies have suggested that alterations in lipid signaling may be one mechanism by which electronic cigarettes contribute to lung pulmonary function. Vitamin E acetate, for example, is synthetic form of Vitamin E transported via lipids, found to be associated with electronic cigarette associated lung injury. Lipids are absolutely critical for normal lung physiology and perturbations in a number of lipid pathways have been associated with respiratory illness. Is it conceivable that electronic cigarette use even in seemingly healthy cohorts are associated with alterations in lipid pathways?
To investigate quantitative alterations in the plasma lipidome associated with electronic cigarette use in healthy we obtained plasma samples from 119 male and female participants with who were either: (1) chronic tobacco cigarette (TC) smokers (> 12 months of self-reported TC use), (2) chronic Electronic cigarette (EC) users (> 12 months of self-reported EC use), or (3) non-users. We measured quantitative lipid species across different lipid sub-classes from plasma samples using the Sciex Lipidyzer.
We found that male and female tobacco and electronic cigarette users had distinct lipidome signatures across a number of lipid species although the vast majority of lipids were unchanged when compared to non-users. Intriguingly, we found that female but not male electronic cigarette users had lower levels of plasmalogens, critical glycerophospholipids secreted by alveoli and required for normal surfactant function.
In summary, our study does not reveal striking changes associated with electronic cigarette use but we observed sex-specific changes in lipids known to be critical for lung function.
尽管有多项报告将电子烟与不良健康后果联系起来，但电子烟的使用仍在增加。最近的研究表明，脂质信号的改变可能是电子烟影响肺功能的一种机制。例如，维生素E醋酸酯是一种通过脂质运输的维生素E合成形式，被发现与电子烟相关的肺损伤有关。脂质对于正常的肺生理功能至关重要，许多脂质途径的紊乱都与呼吸系统疾病有关。是否可以想象，即使在看似健康的人群中使用电子烟也与脂质途径的改变有关？
为了研究健康人群中与电子烟使用相关的血浆脂质组的定量变化，我们从119名男性和女性参与者中获取了血浆样本，这些参与者分为以下三类：（1）长期吸烟（TC）者（自我报告使用TC超过12个月），（2）长期使用电子烟（EC）者（自我报告使用EC超过12个月），或（3）非使用者。我们使用Sciex Lipidyzer测量了血浆样本中不同脂质亚类的定量脂质种类。
我们发现，男性和女性的烟草和电子烟使用者在许多脂质种类上有不同的脂质组特征，尽管与非使用者相比，绝大多数脂质没有变化。有趣的是，我们发现女性电子烟使用者而非男性使用者的缩醛磷脂水平较低，缩醛磷脂是肺泡分泌的关键甘油磷脂，对正常表面活性剂功能至关重要。
总之，我们的研究没有揭示与电子烟使用相关的显著变化，但我们观察到了对肺功能至关重要的脂质的性别特异性变化。
