Alven Sibusiso, Nqoro Xhamla, Aderibigbe Blessing Atim
Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South Africa.
Polymers (Basel). 2020 Oct 6;12(10):2286. doi: 10.3390/polym12102286.
Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the and therapeutic outcomes of wound dressings loaded with curcumin.
目前使用的一些伤口敷料具有有趣的特性，如优异的孔隙率、良好的吸水能力、适度的水汽透过率、高载药效率以及提供湿润环境的良好能力，但它们在抗菌性能方面存在局限性。它们无法保护伤口免受微生物入侵，导致伤口暴露于微生物感染中，从而导致伤口愈合过程延迟。此外，一些伤口敷料含有合成抗生素，可能会对患者产生不良副作用。基于天然的化合物具有独特的特性，如良好的生物相容性、降低的毒性等。姜黄素就是这样一种基于天然的化合物，它已展现出多种生物活性，如抗癌、抗菌和抗氧化特性。其良好的抗菌和抗氧化活性使其对伤口治疗有益。几位研究人员开发了不同类型的负载姜黄素的聚合物基伤口敷料。这些伤口敷料表现出优异的特性，如良好的生物相容性、诱导皮肤再生、加速伤口愈合过程以及出色的抗氧化和抗菌活性。本综述将聚焦于负载姜黄素的伤口敷料的[此处原文缺失部分内容]和治疗效果。
