Ehlers Cindy L, Wills Derek N, Karriker-Jaffe Katherine J, Gilder David A, Phillips Evelyn, Bernert Rebecca A
Department of Neuroscience, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
RTI International, Research Triangle Park, NC 27709, USA.
Behav Sci (Basel). 2020 Oct 7;10(10):154. doi: 10.3390/bs10100154.
Alcohol exposure typically begins in adolescence, and heavy binge drinking is associated with health risk behaviors. Event-related oscillations (EROs) may represent sensitive biomarkers or endophenotypes for early alcohol exposure as well as other risk behaviors such as suicidal thoughts and actions. In this study, young adults (age 18-30 years) of American Indian (AI) ( = 479) and Mexican American (MA) ( = 705) ancestry were clinically assessed, and EROs were generated to happy, sad and neutral faces. Extreme adolescent binge drinking (10+ drinks) was common (20%) in this population of AI/MA and associated with a significantly increased risk of a lifetime history of suicidal acts (SA, suicide attempts, deaths) but not suicidal thoughts (ST, ideation, plans). ST were reported among MA participants, whereas SA were more common among AI young adults. Extreme adolescent binge drinking was also associated with errors in detection of sad and neutral faces, increases in delta ERO energy, and decreases in phase locking (PL), particularly in parietal areas. A lifetime history of ST was associated with increases in delta ERO energy and PL, whereas SA were associated with decreases in both. These studies suggest that ERO measures may represent important potential biomarkers of adolescent extreme binge drinking and risk for suicidal behaviors.
饮酒通常始于青春期，大量狂饮与健康风险行为有关。事件相关振荡（EROs）可能是早期酒精暴露以及其他风险行为（如自杀念头和行为）的敏感生物标志物或内表型。在本研究中，对美洲印第安人（AI）（n = 479）和墨西哥裔美国人（MA）（n = 705）血统的年轻成年人（年龄18 - 30岁）进行了临床评估，并针对高兴、悲伤和中性面孔生成了EROs。在这个AI/MA人群中，极端青少年狂饮（10杯及以上）很常见（20%），且与自杀行为（SA，自杀未遂、死亡）的终生风险显著增加相关，但与自杀念头（ST，意念、计划）无关。MA参与者报告有ST，而SA在AI年轻成年人中更常见。极端青少年狂饮还与悲伤和中性面孔检测错误、δ ERO能量增加以及锁相（PL）减少有关，尤其是在顶叶区域。ST的终生史与δ ERO能量和PL增加有关，而SA则与两者减少有关。这些研究表明，EROs测量可能是青少年极端狂饮和自杀行为风险的重要潜在生物标志物。
