Prosolov Konstantin A, Lastovka Vladimir V, Belyavskaya Olga A, Lychagin Dmitry V, Schmidt Juergen, Sharkeev Yurii P
Institute of Strength Physics and Materials Science of SB RAS, Academicheskii Prospect 2/4, 634055 Tomsk, Russia.
Department of Mineralogy and Geochemistry, National Research Tomsk State University, Lenin Avenue 36, 634050 Tomsk, Russia.
Materials (Basel). 2020 Oct 7;13(19):4449. doi: 10.3390/ma13194449.
Titanium-based alloys are known as a "gold standard" in the field of implantable devices. Mg-based alloys, in turn, are very promising biocompatible material for biodegradable, temporary implants. However, the clinical application of Mg-based alloys is currently limited due to the rapid resorption rate in the human body. The deposition of a barrier layer in the form of bioactive calcium phosphate coating is proposed to decelerate Mg-based alloys resorption. The dissolution rate of calcium phosphates is strongly affected by their crystallinity and structure. The structure of antibacterial Cu- and Zn-substituted hydroxyapatite deposited by an radiofrequency (RF) magnetron sputtering on Ti and Mg-Ca substrates is tailored by post-deposition heat treatment and deposition at increased substrate temperatures. It is established that upon an increase in heat treatment temperature mean crystallite size decreases from 47 ± 17 to 13 ± 9 nm. The character of the crystalline structure is not only governed by the temperature itself but relies on the condition such as either post-deposition treatment, where an amorphous calcium phosphate undergoes crystallization or instantaneous crystalline coating growth during deposition on the hot substrate. A higher treatment temperature at 700 °C results in local coating micro-cracking and induced defects, while the temperature of 400-450 °C resulted in the formation of dense, void-free structure.
钛基合金在可植入装置领域被视为“黄金标准”。而镁基合金则是用于可生物降解临时植入物的极具前景的生物相容性材料。然而，由于镁基合金在人体中的快速吸收率，其目前的临床应用受到限制。有人提出以生物活性磷酸钙涂层的形式沉积阻挡层来减缓镁基合金的吸收。磷酸钙的溶解速率受其结晶度和结构的强烈影响。通过射频（RF）磁控溅射在钛和镁钙基底上沉积的抗菌铜和锌取代的羟基磷灰石的结构，可通过沉积后热处理和在升高的基底温度下沉积来进行调整。已确定，随着热处理温度的升高，平均微晶尺寸从47±17纳米减小到13±9纳米。晶体结构的特性不仅取决于温度本身，还依赖于诸如沉积后处理（在此过程中无定形磷酸钙发生结晶）或在热基底上沉积期间瞬时晶体涂层生长等条件。在700℃的较高处理温度会导致局部涂层微裂纹和诱导缺陷，而400 - 450℃的温度则导致形成致密、无孔隙的结构。
