Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, DK-2450 Copenhagen SV, Denmark.
Genes (Basel). 2023 Jan 13;14(1):213. doi: 10.3390/genes14010213.
Characterized by cardiovascular disease and diabetes, cardiometabolic diseases are a major cause of mortality around the world. As such, there is an urgent need to understand the pathogenesis of cardiometabolic diseases. Increasing evidence suggests that most of the mammalian genome are transcribed as RNA, but only a few percent of them encode for proteins. All of the RNAs that do not encode for proteins are collectively called non-protein-coding RNAs (ncRNAs). Among these ncRNAs, long ncRNAs (lncRNAs) are considered as missing keys to understand the pathogeneses of various diseases, including cardiometabolic diseases. Given the increased interest in lncRNAs, in this study, we will summarize the latest trend in the lncRNA research from the perspective of cardiometabolism and disease by focusing on the major risk factors of cardiometabolic diseases: obesity, cholesterol, diabetes, and hypertension. Because genetic inheritance is unavoidable in cardiometabolic diseases, we paid special attention to the genetic factors of lncRNAs that may influence cardiometabolic diseases.
心血管疾病和糖尿病为特征的代谢心血管疾病是全世界死亡的主要原因。因此，迫切需要了解代谢心血管疾病的发病机制。越来越多的证据表明，大多数哺乳动物基因组都被转录为 RNA，但只有少数几个编码蛋白质。所有不编码蛋白质的 RNA 统称为非编码 RNA（ncRNA）。在这些 ncRNA 中，长 ncRNA（lncRNA）被认为是理解包括代谢心血管疾病在内的各种疾病发病机制的关键所在。鉴于人们对 lncRNA 的兴趣日益增加，在这项研究中，我们将从代谢和心血管的角度总结 lncRNA 研究的最新趋势，重点关注代谢心血管疾病的主要危险因素：肥胖、胆固醇、糖尿病和高血压。由于遗传因素在代谢心血管疾病中不可避免，我们特别关注可能影响代谢心血管疾病的 lncRNA 的遗传因素。
