Molina Sarahi G, Beltran Alvaro A, Beltran Adriana S
Human Pluripotent Stem Cell Core, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Department of Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Stem Cell Res. 2020 Dec;49:102015. doi: 10.1016/j.scr.2020.102015. Epub 2020 Oct 1.
Induced pluripotent stem cells (iPSCs) generated from young, healthy individuals are valuable tools for investigating molecular disease mechanisms during the early development of the brain vasculature. We generated an iPSC line from peripheral blood mononuclear cells (PBMCs) isolated from a healthy 13-yeard old female donor using the Sendai virus. The iPSCs differentiated into endothelial cells, astrocytes, and neurons. This iPSC line can serve as a healthy reference control for comparative studies in drug development and modeling the early onset of Cerebral Cavernous Malformation (CCM).
从年轻健康个体产生的诱导多能干细胞（iPSC）是研究脑血管系统早期发育过程中分子疾病机制的宝贵工具。我们使用仙台病毒从一名健康的13岁女性供体分离的外周血单个核细胞（PBMC）中生成了一个iPSC系。这些iPSC分化为内皮细胞、星形胶质细胞和神经元。该iPSC系可作为药物开发和脑海绵状畸形（CCM）早期发病建模比较研究的健康对照。
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