General Studies, Gateway Technical College, Kenosha, WI, 53144, USA.
The Key Laboratory of Aquatic Biodiversity and Conservation of the Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.
Arch Microbiol. 2021 Mar;203(2):683-692. doi: 10.1007/s00203-020-02060-1. Epub 2020 Oct 10.
Bacterial pathogens are a major threat to both humans and animals worldwide. It is crucial to understand the mechanisms of various disease processes at the molecular level. Shewanella species are widespread in the environment and some are considered as emerging opportunistic human and marine mammal pathogens. In this study, putative virulence factors on the genome of Shewanella indica BW, a bacterium isolated from the Bryde's whale (Balaenoptera edeni), were determined. Additionally, for comparative purposes, putative virulence factors from two other S. indica and ten S. algae strains were also determined using the Pathosystems Resource Integration Center (PATRIC) pipeline. We confirmed the presence of previously reported virulence factors and we are proposing several new candidate virulence factors. Interestingly, the putative virulence factors were very similar between the two species with the exception of microbial collagenase which was present in all S. algae genomes, but absent in all S. indica genomes.
细菌病原体对全球的人类和动物都构成了重大威胁。了解各种疾病过程在分子水平上的机制至关重要。希瓦氏菌属在环境中广泛存在，其中一些被认为是新兴的机会性人类和海洋哺乳动物病原体。在这项研究中，确定了从布氏鲸（Balaenoptera edeni）中分离出的细菌希瓦氏菌 BW 的基因组上的假定致病因子。此外，为了进行比较，还使用病原体系统资源整合中心（PATRIC）管道确定了来自另外两种希瓦氏菌和十种希瓦氏藻菌株的假定致病因子。我们证实了先前报道的致病因子的存在，并提出了几个新的候选致病因子。有趣的是，除了微生物胶原酶外，两种物种之间的假定致病因子非常相似，微生物胶原酶存在于所有希瓦氏藻基因组中，但不存在于所有希瓦氏菌属基因组中。
