Parsonnet K C, Kass E H
Antimicrob Agents Chemother. 1987 Jun;31(6):911-4. doi: 10.1128/AAC.31.6.911.
The magnitude of the risk of acquiring infections due to antibiotic-resistant bacteria, as a consequence of prolonged contact with such bacteria, is unclear. We compared antibiotic resistance patterns of Escherichia coli isolated from the urine of bacteriuric female abattoir workers with resistance patterns of E. coli cultured from 190 poultry taken from the processing line. We found E. coli in 181 (95%) of the poultry cultures; 96% of the isolates were resistant to one or more antibiotics, and 87% were multiply resistant. Of the 649 women whose urine was cultured and who had not recently received antibiotic therapy, 69 (10.6%) had positive urine cultures, with E. coli accounting for 67% of the isolates. Of the 46 E. coli isolates, 8 (17.4%) were resistant to one or more antibiotics. All of the antibiograms of the urinary isolates were unique, and only one, a strain with resistance only to streptomycin, matched those of any of the poultry isolates. Of the women tested for bacteriuria, 74 had taken antibiotics within 3 months of culture, and these women were analyzed separately. Among the recent antibiotic users, six (8.1%) had positive urine cultures, all with E. coli. Four of these isolates were resistant to at least one antibiotic; all had patterns that matched at least one of the poultry isolates. Therefore, in a population of female abattoir workers who were not receiving antibiotic therapy, despite a high exposure to resistant microorganisms of animal origin, infections were infrequently caused by organisms with resistance patterns characteristic of the livestock to which the women were heavily exposed.
由于与抗生素耐药菌长期接触而感染此类细菌的风险程度尚不清楚。我们比较了从有菌尿的女性屠宰场工人尿液中分离出的大肠杆菌的抗生素耐药模式与从加工线上采集的190只家禽中培养出的大肠杆菌的耐药模式。我们在181份（95%）家禽培养物中发现了大肠杆菌；96%的分离株对一种或多种抗生素耐药，87%为多重耐药。在649名尿液进行培养且近期未接受抗生素治疗的女性中，69名（10.6%）尿液培养呈阳性，其中大肠杆菌占分离株的67%。在46株大肠杆菌分离株中，8株（17.4%）对一种或多种抗生素耐药。所有尿液分离株的抗菌谱都是独特的，只有一株仅对链霉素耐药的菌株与任何家禽分离株的抗菌谱匹配。在接受菌尿检测的女性中，74名在培养前3个月内使用过抗生素，这些女性被单独分析。在近期使用过抗生素的女性中，6名（8.1%）尿液培养呈阳性，均为大肠杆菌。其中4株分离株对至少一种抗生素耐药；所有菌株的模式都与至少一种家禽分离株匹配。因此，在未接受抗生素治疗的女性屠宰场工人人群中，尽管大量接触了动物源耐药微生物，但感染很少由具有她们大量接触的家畜特征性耐药模式的生物体引起。
