Elsayed Sarah M, Reddy Mithun K, Murthy Pooja M, Gupta Ishita, Valiuskyte Monika, Sánchez Diana F, Diaz Mark Anthony
Internal Medicine, Ain Shams University, Faculty of Medicine, Cairo, EGY.
Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, IND.
Cureus. 2020 Sep 5;12(9):e10264. doi: 10.7759/cureus.10264.
The severe acute respiratory distress syndrome coronavirus-2 (SARS-Cov-2) is a novel coronavirus that is believed to be mainly transmitted via droplet and contact transmission. While research is focusing on epidemiology, transmission, vaccine development, and therapeutics for coronavirus disease 2019 (COVID-19), there is a possibility of disease relapse. There are reports of patients who tested positive for SARS-Cov-2 after clinical recovery and initial clearance of the virus. Objective This systematic review aims to identify the trends of COVID-19 relapse, the effects of co-morbidities on it, and associated mortality rates. Methods We conducted a systematic search during March and April 2020 for research articles on the relapse of COVID-19 using two primary databases, PubMed and Embase. Results A total of 13 eligible studies were screened of which 11 (case reports) were eligible for data extraction. The earliest to report relapse was after two days of discharge and the latest was 22 days after discharge. The mean number of days to relapse was 12 days and the median number was seven days. There was incomplete information about comorbidities. No mortalities were reported at the time of the study.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是一种新型冠状病毒，据信主要通过飞沫和接触传播。虽然研究重点集中在2019冠状病毒病（COVID-19）的流行病学、传播、疫苗研发和治疗方法上，但仍有可能出现疾病复发。有报告称，一些患者在临床康复且病毒最初清除后，SARS-CoV-2检测呈阳性。目的本系统评价旨在确定COVID-19复发的趋势、合并症对其的影响以及相关死亡率。方法我们在2020年3月和4月期间，使用两个主要数据库PubMed和Embase，对关于COVID-19复发的研究文章进行了系统检索。结果共筛选出13项符合条件的研究，其中11项（病例报告）符合数据提取条件。最早报告复发的时间是出院后两天，最晚是出院后22天。复发的平均天数为12天，中位数为7天。关于合并症的信息不完整。研究时未报告死亡病例。
