Rafferty P, Tweeddale P M, Ferguson R J, Biggs B A, Grant I W
Br J Clin Pharmacol. 1987 Jul;24(1):100-2. doi: 10.1111/j.1365-2125.1987.tb03143.x.
Eight asthmatic patients completed a 12-week, double-blind, placebo controlled study to assess the efficacy of ketotifen, 1 mg twice daily, in the inhibition of bronchoconstriction induced by isocapnic hyperventilation (IH). There was no significant difference in the degree of bronchoconstriction produced by IH after treatment with ketotifen or placebo.
八名哮喘患者完成了一项为期12周的双盲、安慰剂对照研究，以评估每日两次服用1毫克酮替芬对抑制等碳酸过度通气（IH）诱发支气管收缩的疗效。服用酮替芬或安慰剂治疗后，IH诱发的支气管收缩程度无显著差异。
