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以红豆蔻凝集素靶向受体结合域的聚糖作为开发抗COVID-19治疗方法的新途径。

Targeting the glycan of receptor binding domain with jacalin as a novel approach to develop a treatment against COVID-19.

作者信息

Rajendaran Senthilnathan, Jothi Arunchalam, Anbazhagan Veerappan

机构信息

School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu 613 413, India.

出版信息

R Soc Open Sci. 2020 Sep 23;7(9):200844. doi: 10.1098/rsos.200844. eCollection 2020 Sep.

DOI:10.1098/rsos.200844
PMID:33047045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7540766/
Abstract

analysis revealed that a lectin, jacalin from jackfruit seeds, recognizes a glycosylated region of the receptor-binding domain (RBD) of SARS-CoV2. Jacalin binding induces conformational changes in RBD and significantly affects its interaction with human angiotensin-converting enzyme 2. The result may open up exploration of lectin-based strategies against COVID-19.

摘要

分析表明，一种来自菠萝蜜种子的凝集素——jacalin，能够识别严重急性呼吸综合征冠状病毒2（SARS-CoV2）受体结合域（RBD）的一个糖基化区域。jacalin的结合会诱导RBD的构象变化，并显著影响其与人类血管紧张素转换酶2的相互作用。这一结果可能会开启针对2019冠状病毒病基于凝集素策略的探索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b0/7540766/4a1fc3d60a33/rsos200844-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b0/7540766/d59d7296e07c/rsos200844-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b0/7540766/0ff99ee54827/rsos200844-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b0/7540766/4832ac6db3b2/rsos200844-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b0/7540766/4a1fc3d60a33/rsos200844-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b0/7540766/d59d7296e07c/rsos200844-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b0/7540766/0ff99ee54827/rsos200844-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b0/7540766/4832ac6db3b2/rsos200844-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b0/7540766/4a1fc3d60a33/rsos200844-g4.jpg

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