Department of Plant and Microbial Biology, Microbial and Plant Genomics Institute, University of Minnesota, St. Paul, MN 55108, U.S.A.
State Key Laboratory of Agricultural Microbiology, Interdisciplinary Sciences Research Institute, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Mol Plant Microbe Interact. 2021 Jan;34(1):3-14. doi: 10.1094/MPMI-08-20-0239-IA. Epub 2020 Dec 2.
This article is part of the Top 10 Unanswered Questions in MPMI invited review series.Plants recognize the presence or invasion of microbes through cell surface-localized pattern recognition receptors (PRRs) and intracellular nucleotide-binding domain leucine-rich repeat receptors (NLRs). Although PRRs and NLRs are activated by ligands located in different subcellular compartments through distinct mechanisms, signals initiated from PRRs and NLRs converge into several common signaling pathways with different dynamics. Increasing evidence suggests that PRR- and NLR-mediated signaling extensively crosstalk and such interaction can greatly influence immune response outcomes. Sophisticated experimental setups enabled dissection of the signaling events downstream of PRRs and NLRs with fine temporal and spatial resolution; however, the molecular links underlying the observed interactions in PRR and NLR signaling remain to be elucidated. In this review, we summarize the latest knowledge about activation and signaling mediated by PRRs and NLRs, deconvolute the intimate association between PRR- and NLR-mediated signaling, and propose hypotheses to guide further research on key topics.[Formula: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license.
这篇文章是 MPMI 十大未解问题特邀综述系列的一部分。植物通过细胞表面定位的模式识别受体 (PRRs) 和细胞内核苷酸结合域富含亮氨酸重复受体 (NLRs) 识别微生物的存在或入侵。虽然 PRRs 和 NLRs 通过不同的机制被位于不同亚细胞区室的配体激活，但 PRRs 和 NLRs 启动的信号在几个具有不同动力学的共同信号通路中汇聚。越来越多的证据表明，PRR 和 NLR 介导的信号广泛相互作用，这种相互作用可以极大地影响免疫反应的结果。复杂的实验设置使我们能够以精细的时空分辨率来剖析 PRRs 和 NLRs 下游的信号事件；然而，PRR 和 NLR 信号中观察到的相互作用的分子联系仍有待阐明。在这篇综述中，我们总结了关于 PRRs 和 NLRs 介导的激活和信号的最新知识，阐明了 PRR 和 NLR 介导的信号之间的密切联系，并提出了假设，以指导关于关键主题的进一步研究。[公式：见正文] 版权所有 © 2021 作者。这是一个在 CC BY-NC-ND 4.0 国际许可下发布的开放获取文章。
