Antiproliferative and Antimigration Activities of Beauvericin Isolated from sp. on Pancreatic Cancer Cells.

This study describes the antiproliferative and antimigration effects of beauvericin from a culture broth of sp. in human pancreatic cancer cells (PANC-1). Activity-guided fractionation of the EtOAc extract of cultured broth of sp. RD055140 afforded beauvericin (), a new isariotin derivative, 7--methylisariotin C (), together with the known isariotin analogs, TK-57-164A () and B (). As a result of the measurement of the cell viability, inhibited cell growth (IC = 4.8 µM) of PANC-1 cells. Furthermore, was found to inhibit the migration activity of PANC-1 cells by upregulating the expression of the gene and reducing and genes in a dose-dependent manner (0.1-1 µM). These activities of had lower concentrations than the cytotoxic activity. These findings suggest that can be used as an anticancer agent against human pancreatic carcinoma.