伊萨里奥菌素E和F，来自昆虫病原真菌细脚棒束孢BCC 12625的螺环和双环半缩醛。

Isariotins E and F, spirocyclic and bicyclic hemiacetals from the entomopathogenic fungus Isaria tenuipes BCC 12625.

作者信息

Bunyapaiboonsri Taridaporn, Yoiprommarat Seangaroon, Intereya Kamolphan, Rachtawee Pranee, Hywel-Jones Nigel L, Isaka Masahiko

机构信息

National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani, Thailand.

出版信息

J Nat Prod. 2009 Apr;72(4):756-9. doi: 10.1021/np800702c.

DOI:10.1021/np800702c

PMID:19265430

Abstract

New spirocyclic and bicyclic hemiacetals, isariotins E (1) and F (2), together with TK-57-164A (3) were isolated from the entomopathogenic fungus Isaria tenuipes BCC 12625. The absolute configuration of 3 was addressed by application of the modified Mosher's method. Isariotin F (2) exhibited activity against the malaria parasite Plasmodium falciparum K1 with an IC(50) value of 5.1 microM and cytotoxic activities against cancer cell lines (KB, BC, and NCI-H187) and nonmalignant (Vero) cells with respective IC(50) values of 15.8, 2.4, 1.6, and 2.9 microM.

摘要

从昆虫病原真菌细脚棒束孢Isaria tenuipes BCC 12625中分离得到了新的螺环和双环半缩醛化合物——异座菌素E（1）和F（2），以及TK - 57 - 164A（3）。通过应用改良的莫舍尔方法确定了3的绝对构型。异座菌素F（2）对恶性疟原虫K1表现出活性，IC50值为5.1 μM，对癌细胞系（KB、BC和NCI - H187）和非恶性（Vero）细胞具有细胞毒活性，相应的IC50值分别为15.8、2.4、1.6和2.9 μM。