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来自内生真菌sp. shj2的细胞松弛素及其抗迁移活性。

Cytochalasans from the Endophytic Fungus sp. shj2 and Their Antimigratory Activities.

作者信息

Yan Bing-Chao, Wang Wei-Guang, Kong Ling-Mei, Tang Jian-Wei, Du Xue, Li Yan, Puno Pema-Tenzin

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.

Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China.

出版信息

J Fungi (Basel). 2022 May 23;8(5):543. doi: 10.3390/jof8050543.

DOI:10.3390/jof8050543
PMID:35628798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9143583/
Abstract

Cytochalasans from the endophytic fungi featured structure diversity. Our previous study has disclosed that cytochalasans from the endophytic fungus sp. shj2 exhibited an antimigratory effect. Further chemical investigation on sp. shj2 has led to the discovery of seven new cytochalasans (-), together with four known ones. Their structures were elucidated through extensive spectroscopic data interpretation and single-crystal X-ray diffraction analysis. Compounds - and - exhibited antimigratory effects against MDA-MB-231 in vitro with IC values in the range of 1.01-10.42 μM.

摘要

来自内生真菌的细胞松弛素具有结构多样性。我们之前的研究表明，内生真菌sp. shj2产生的细胞松弛素具有抗迁移作用。对sp. shj2的进一步化学研究发现了7种新的细胞松弛素（-），以及4种已知的细胞松弛素。通过广泛的光谱数据分析和单晶X射线衍射分析阐明了它们的结构。化合物-和-在体外对MDA-MB-231具有抗迁移作用，IC值在1.01-10.42μM范围内。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf9/9143583/c7a9a5a4610c/jof-08-00543-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf9/9143583/f15a32dac4c2/jof-08-00543-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf9/9143583/8a76a5d473c9/jof-08-00543-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf9/9143583/70c7ddde6779/jof-08-00543-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf9/9143583/c7a9a5a4610c/jof-08-00543-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf9/9143583/f15a32dac4c2/jof-08-00543-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf9/9143583/8a76a5d473c9/jof-08-00543-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf9/9143583/70c7ddde6779/jof-08-00543-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf9/9143583/c7a9a5a4610c/jof-08-00543-g004.jpg

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J Antibiot (Tokyo). 2022 Jul;75(7):410-414. doi: 10.1038/s41429-022-00527-5. Epub 2022 Apr 22.
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