Post Graduate Department of Biotechnology, Utkal University, Vani Vihar, Bhubaneswar-751004, Odisha,India.
Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyangsi 10326,Korea.
Curr Pharm Biotechnol. 2022;23(1):72-97. doi: 10.2174/1389201021666201013153142.
Nutritional supplementations are a form of nutrition sources that may help in improving the health complexities of a person throughout his or her life span. Being also categorized as food supplementations, nutraceuticals are products that are extracted from edible sources with medical benefits as well as primary nutritional values. Nutraceuticals can be considered as functional foods. There are evidences that nutraceutical supplementations can alter the commensal gut microbiota and help to prevent or fight against chronic non-communicable degenerative diseases in adults, including neurological disorders (Autism Spectrum Disorder [ASD], Parkinson's disease [PD], Multiple sclerosis [MS]) and metabolic disorders (Type-II diabetes, obesity and non-alcoholic fatty liver disease). They can even lessen the complexities of preterm babies like extra-uterine growth restriction, necrotizing enterocolitis, infant eczema and allergy (during pregnancy) as well as bronchopulmonary dysplasia. Molecular perception of inflammatory and apoptotic modulators regulating the pathogenesis of these health risks, their control and management by probiotics and prebiotics could further emphasize the scientific overview of their utility. In this study, the pivotal role of nutraceutical supplementations in regulating or modulating molecular pathways in the above non-communicable diseases is briefly described. This work also gives an overall introduction of the sophisticated genome-editing techniques and advanced delivery systems in therapeutic activities applicable under these health risks.
营养补充剂是一种营养来源，有助于改善一个人在整个生命周期中的健康复杂性。营养补充剂也被归类为食品补充剂，是从具有医疗益处和主要营养价值的可食用来源中提取的产品。营养补充剂可以被认为是功能性食品。有证据表明，营养补充剂可以改变共生肠道微生物群，有助于预防或对抗成年人的慢性非传染性退行性疾病，包括神经紊乱（自闭症谱系障碍[ASD]、帕金森病[PD]、多发性硬化症[MS]）和代谢紊乱（二型糖尿病、肥胖和非酒精性脂肪肝疾病）。它们甚至可以减轻早产儿的复杂性，如宫外生长受限、坏死性小肠结肠炎、婴儿湿疹和过敏（怀孕期间）以及支气管肺发育不良。对调节这些健康风险发病机制的炎症和凋亡调节剂的分子感知，通过益生菌和益生元对其进行控制和管理，可以进一步强调它们的应用的科学概述。在这项研究中，简要描述了营养补充剂在调节或调节上述非传染性疾病中分子途径的关键作用。这项工作还全面介绍了适用于这些健康风险的复杂基因组编辑技术和先进的传递系统。
