Klastersky J, Prévost J M, Meunier-Carpentier F, Daneau D, Gerard M
J Clin Pharmacol. 1977 Aug-Sep;17(8-9):520-8. doi: 10.1002/j.1552-4604.1977.tb05645.x.
Sisomicin was administered as a single daily intramuscular injection (160 mg) or as two daily injections (80 mg) to 50 patients with bacteriuria superimposed on chronic urologic diseases in a randomized controlled fashion. The administration of two daily doses was significantly more effective (P less than 0.01) in achieving cure than the injection of a single daily dose. The renal function, as expressed by creatinine clearance, became impaired significantly more often (P less than 0.05) in the patients receiving the single daily dose of sisomicin.
以随机对照方式，对50例患有慢性泌尿系统疾病并伴有菌尿症的患者，每日单次肌内注射西索米星（160毫克）或每日两次注射（80毫克）。每日两次给药在实现治愈方面比每日单次注射显著更有效（P小于0.01）。以肌酐清除率表示的肾功能，在接受每日单次剂量西索米星的患者中显著更频繁地受损（P小于0.05）。
