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雾霭、诱惑与成瘾:雾化吸入的肺部效应及其主要液体成分的作用

The fog, the attractive and the addictive: pulmonary effects of vaping with a focus on the contribution of each major vaping liquid constituent.

机构信息

Quebec Heart and Lung Institute, Université Laval, Quebec, Canada.

Faculty of Medicine, Université Laval, Quebec, Canada.

出版信息

Eur Respir Rev. 2020 Oct 15;29(157). doi: 10.1183/16000617.0268-2020. Print 2020 Sep 30.

DOI:10.1183/16000617.0268-2020
PMID:33060167
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9489038/
Abstract

Vaping has become increasingly popular over the past decade. This pragmatic review presents the published biological effects of electronic cigarette vapour inhalation with a focus on the pulmonary effects. Special attention has been devoted to providing the documented effects specific to each major ingredient, namely propylene glycol/glycerol, nicotine and flavouring agents. For each ingredient, findings are divided according to the methodology used, being studies, animal studies and clinical studies. Finally, we provide thoughts and insights on the current state of understanding of the pulmonary effects of vaping, as well as novel research avenues and methodologies.

摘要

在过去的十年中,蒸气吸入(vaping)变得越来越流行。本实践综述介绍了已发表的电子香烟蒸气吸入的生物学效应,重点是肺部效应。特别注意提供了针对每个主要成分(即丙二醇/甘油、尼古丁和调味剂)的有文件记录的特定影响。对于每个成分,根据所使用的方法将研究结果进行了划分,即研究、动物研究和临床研究。最后,我们对目前对蒸气吸入肺部效应的理解状况,以及新的研究途径和方法,提供了一些思考和见解。

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Eur Respir Rev. 2020 Oct 15;29(157). doi: 10.1183/16000617.0268-2020. Print 2020 Sep 30.
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[E-cigarettes also contain detrimental chemicals].电子烟也含有有害化学物质。
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本文引用的文献

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Exposure to nicotine-free and flavor-free e-cigarette vapors modifies the pulmonary response to tobacco cigarette smoke in female mice.暴露于不含尼古丁和调味剂的电子烟蒸汽会改变雌性小鼠对香烟烟雾的肺部反应。
Am J Physiol Lung Cell Mol Physiol. 2020 Oct 1;319(4):L717-L727. doi: 10.1152/ajplung.00037.2020. Epub 2020 Aug 26.
2
Electronic-Cigarette Vehicles and Flavoring Affect Lung Function and Immune Responses in a Murine Model.电子烟车辆和调味剂会影响小鼠模型的肺功能和免疫反应。
Int J Mol Sci. 2020 Aug 21;21(17):6022. doi: 10.3390/ijms21176022.
3
Pulmonary Toxicity and Inflammatory Response of E-Cigarette Vape Cartridges Containing Medium-Chain Triglycerides Oil and Vitamin E Acetate: Implications in the Pathogenesis of EVALI.含中链甘油三酯油和维生素E醋酸酯的电子烟弹的肺毒性和炎症反应:对电子烟或雾化产品使用相关肺损伤发病机制的启示
Toxics. 2020 Jun 28;8(3):46. doi: 10.3390/toxics8030046.
4
Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells.电子香烟蒸气适度刺激人单核细胞来源树突状细胞的促炎信号通路和白细胞介素-6 的产生。
Arch Toxicol. 2020 Jun;94(6):2097-2112. doi: 10.1007/s00204-020-02757-8. Epub 2020 May 5.
5
Nicotine-Free e-Cigarette Vapor Exposure Stimulates IL6 and Mucin Production in Human Primary Small Airway Epithelial Cells.无尼古丁电子烟烟雾暴露刺激人原代小气道上皮细胞中白细胞介素6和粘蛋白的产生。
J Inflamm Res. 2020 Apr 16;13:175-185. doi: 10.2147/JIR.S244434. eCollection 2020.
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Neuroinflammatory and Behavioral Outcomes Measured in Adult Offspring of Mice Exposed Prenatally to E-Cigarette Aerosols.电子烟气溶胶暴露致孕鼠后代的神经炎症和行为学结局。
Environ Health Perspect. 2020 Apr;128(4):47006. doi: 10.1289/EHP6067. Epub 2020 Apr 15.
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Chemical Constituents Involved in E-Cigarette, or Vaping Product Use-Associated Lung Injury (EVALI).与电子烟或雾化产品使用相关的肺损伤(EVALI)中涉及的化学成分。
Toxics. 2020 Apr 3;8(2):25. doi: 10.3390/toxics8020025.
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Toxicity and Chemical Characterization of Aerosol Derived from Electronic Cigarette Humectants Using a Newly Developed Exposure System.使用新开发的暴露系统对电子烟保湿剂产生的气溶胶进行毒性和化学特性分析
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An Animal Model of Inhaled Vitamin E Acetate and EVALI-like Lung Injury.吸入维生素E醋酸酯与电子烟或维生素E醋酸酯相关肺损伤的动物模型
N Engl J Med. 2020 Mar 19;382(12):1175-1177. doi: 10.1056/NEJMc2000231. Epub 2020 Feb 26.
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In utero exposures to electronic-cigarette aerosols impair the signaling during mouse lung development.在子宫内暴露于电子烟气雾会损害小鼠肺发育过程中的信号转导。
Am J Physiol Lung Cell Mol Physiol. 2020 Apr 1;318(4):L705-L722. doi: 10.1152/ajplung.00408.2019. Epub 2020 Feb 21.