Kruszyńska Ewa, Łoboz-Rudnicka Maria, Palombo Carlo, Vriz Olga, Kozakova Michaela, Ołpińska Bogusława, Morizzo Carmela, Łoboz-Grudzień Krystyna, Jaroch Joanna
Cardiology Department, T. Marciniak Hospital, Emergency Medicine Center, Wrocław, Poland.
Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, School of Medicine, Pisa, Italy.
Diabetes Metab Syndr Obes. 2020 Sep 25;13:3359-3369. doi: 10.2147/DMSO.S262192. eCollection 2020.
The effect of metabolic syndrome (MS) on carotid stiffness (CS) in the context of gender is under research.
We examined the relationship between the MS and CS in men (M) and women (W) and investigated if the impact of cardiovascular risk factors on CS is modulated by gender.
The study included 419 subjects (mean age 54.3 years): 215 (51%) with MS (109 W and 106 M) and 204 (49%) without MS (98 W and 106 M). Carotid intima-media thickness (IMT) and CS parameters (beta stiffness index (beta), Peterson's elastic modulus (Ep), arterial compliance (AC) and one-point pulse wave velocity (PWV-beta)) were measured with the echo-tracking (eT) system.
ANCOVA demonstrated that MS was associated with elevated CS indices (p = 0.003 for beta and 0.025 for PWV-beta), although further sex-specific analysis revealed that this relationship was significant only in W (p = 0.021 for beta). Age was associated with CS in both M and W, pulse pressure (PP) and body mass index turned out to be determinants of CS solely in W, while the effect of mean arterial pressure (MAP) and heart rate was more pronounced in M. MANOVA performed in subjects with MS revealed that age and diabetes mellitus type 2 were determinants of CS in both sexes, diastolic blood pressure and MAP - solely in M and systolic blood pressure, PP and waist circumference - solely in W (the relationship between the waist circumference and AC was paradoxical).
The relationship between MS and CS is stronger in W than in M. In subjects with MS, various components of arterial pressure exert different sex-specific effects on CS - with the impact of the pulsative component of arterial pressure (PP) observed in W and the impact of the steady component (MAP) observed in M.
代谢综合征（MS）对颈动脉僵硬度（CS）在性别方面的影响正在研究中。
我们研究了男性（M）和女性（W）中MS与CS之间的关系，并调查了心血管危险因素对CS的影响是否受性别调节。
该研究纳入419名受试者（平均年龄54.3岁）：215名（51%）患有MS（109名女性和106名男性），204名（49%）未患MS（98名女性和106名男性）。使用回声跟踪（eT）系统测量颈动脉内膜中层厚度（IMT）和CS参数（β僵硬度指数（β）、彼得森弹性模量（Ep）、动脉顺应性（AC）和单点脉搏波速度（PWV-β））。
协方差分析表明MS与CS指标升高相关（β为p = 0.003，PWV-β为p = 0.025），尽管进一步的性别特异性分析显示这种关系仅在女性中显著（β为p = 0.021）。年龄在男性和女性中均与CS相关，脉压（PP）和体重指数仅在女性中是CS的决定因素，而平均动脉压（MAP）和心率的影响在男性中更明显。对患有MS的受试者进行的多变量方差分析显示，年龄和2型糖尿病是两性CS的决定因素，舒张压和MAP仅在男性中是决定因素，收缩压、PP和腰围仅在女性中是决定因素（腰围与AC之间的关系是矛盾的）。
MS与CS之间的关系在女性中比在男性中更强。在患有MS的受试者中，动脉压的各个组成部分对CS产生不同的性别特异性影响——在女性中观察到动脉压脉动成分（PP）的影响，在男性中观察到稳定成分（MAP）的影响。
