Xu Yayun, Chen Feihu
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People's Republic of China.
The Key Laboratory of Major Autoimmune Diseases of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, People's Republic of China.
J Inflamm Res. 2020 Sep 28;13:607-617. doi: 10.2147/JIR.S273446. eCollection 2020.
Nesfatin-1, a newly identified energy-regulating peptide, is widely expressed in the central and peripheral tissues, and has a variety of physiological activities. A large number of recent studies have shown that nesfatin-1 exhibits antioxidant, anti-inflammatory, and anti-apoptotic properties and is involved in the occurrence and progression of various diseases. This review summarizes current data focusing on the therapeutic effects of nesfatin-1 under different pathophysiological conditions and the mechanisms underlying its antioxidant, anti-inflammatory, and anti-apoptotic activities.
Nesfatin-1是一种新发现的能量调节肽，广泛表达于中枢和外周组织，并具有多种生理活性。最近大量研究表明，nesfatin-1具有抗氧化、抗炎和抗凋亡特性，并参与各种疾病的发生和发展。本综述总结了当前关于nesfatin-1在不同病理生理条件下的治疗作用及其抗氧化、抗炎和抗凋亡活性机制的数据。
