Han Shuwen, Zhuang Jing, Wu Yinhang, Wu Wei, Yang Xi
Department of Oncology, Huzhou Cent Hospital, Affiliated Cent Hospital HuZhou University, Huzhou 313000, People's Republic of China.
Graduate School of Nursing, Huzhou University, Huzhou 313000, People's Republic of China.
Cancer Manag Res. 2020 Sep 21;12:8703-8720. doi: 10.2147/CMAR.S268943. eCollection 2020.
Intestinal flora is an important component in the human body, which have been reported to be involved in the occurrence and development of colorectal cancer (CRC). Indeed, changes in the intestinal flora in CRC patients compared to those in control subjects have been reported. Several bacterial species have been shown to exhibit the pro-inflammatory and pro-carcinogenic properties, which could consequently have an impact on colorectal carcinogenesis. In this review, we summarize the current knowledge on the potential links between the intestinal microbiota and CRC. We illustrated the mechanisms by which intestinal flora imbalance affects CRC, mainly focusing on inflammation, microbial metabolites, and specific bacteria species. In addition, we discuss how a diet exhibits a strong impact on microbial composition and provides risks for developing CRC. Finally, we describe the potential future directions that are based on intestinal microbiota manipulation for CRC diagnosis and treatment.
肠道菌群是人体的重要组成部分，据报道其与结直肠癌（CRC）的发生和发展有关。事实上，已有报道称CRC患者的肠道菌群与对照受试者相比存在变化。几种细菌已被证明具有促炎和促癌特性，这可能会对结直肠癌的发生产生影响。在本综述中，我们总结了目前关于肠道微生物群与CRC之间潜在联系的知识。我们阐述了肠道菌群失衡影响CRC的机制，主要集中在炎症、微生物代谢产物和特定细菌种类上。此外，我们讨论了饮食如何对微生物组成产生强烈影响并增加患CRC的风险。最后，我们描述了基于肠道微生物群调控用于CRC诊断和治疗的潜在未来方向。
