Department of Optics, Laboratory of Vision Sciences and Applications, University of Granada, Granada, Spain.
Graefes Arch Clin Exp Ophthalmol. 2021 Apr;259(4):919-928. doi: 10.1007/s00417-020-04978-0. Epub 2020 Oct 16.
The purpose of this work was to evaluate possible changes in accommodation dynamics caused by the intake of different doses of alcohol.
A total of 20 emmetropic subjects took part in the study. This involved a baseline session, a session after consuming 300 ml of red wine, and another after consuming 450 ml of the same wine. The accommodation dynamics were characterized for two target vergences (2.5D and 5.0D) using the Grand Seiko WAM-5500 autorefractor, which provided the accommodation and disaccommodation variables. The accommodative facility was measured using flippers of ± 2.00 D.
The mean accommodation velocities and velocity peaks were significantly lower after consuming alcohol for the higher intake, particularly for 5.0D (p < 0.05). The response time was significantly higher only for the high-intake condition for 5.0D (p < 0.05). The accommodative microfluctuations were significantly higher for both target vergences for the high-intake condition (p < 0.05). The accommodative facility was significantly impaired in both intake conditions (p < 0.05). The breath alcohol content (BrAC) was correlated with the deterioration of some variables: the accommodative facility (ρ = 0.490), and the velocity peak for 2.5D (ρ = 0.349) and 5.0D (ρ = 0.387).
Alcohol intake affects accommodation dynamics, causing deterioration in the mean velocity, velocity peak, response time, accommodative microfluctuations, and accommodative facility, especially for the target vergence of 5.0D and high alcohol dosages.
本研究旨在评估摄入不同剂量酒精对调节动态的影响。
共 20 名正视眼受试者参与了本研究。该研究包括基础阶段、饮用 300ml 红酒后阶段和饮用相同红酒 450ml 后阶段。使用 Grand Seiko WAM-5500 自动折射仪对两个目标离焦量(2.5D 和 5.0D)的调节动态进行了特征描述,该仪器提供了调节和离焦变量。使用±2.00D 的翻转镜来测量调节灵活性。
酒精摄入量较高时,平均调节速度和速度峰值显著降低,尤其是 5.0D(p<0.05)。仅在高摄入量条件下,5.0D 的反应时间显著升高(p<0.05)。高摄入量条件下,两个目标离焦量的调节微波动均显著升高(p<0.05)。两种摄入量条件下的调节灵活性均显著受损(p<0.05)。呼吸酒精含量(BrAC)与一些变量的恶化相关:调节灵活性(ρ=0.490),2.5D 的速度峰值(ρ=0.349)和 5.0D 的速度峰值(ρ=0.387)。
酒精摄入会影响调节动态,导致平均速度、速度峰值、反应时间、调节微波动和调节灵活性下降,尤其是在 5.0D 的目标离焦量和高酒精剂量下。