Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, 28029 Madrid, Spain.
Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, 28029 Madrid, Spain.
Nutrients. 2020 Oct 14;12(10):3132. doi: 10.3390/nu12103132.
This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR) = 0.44; 95% confidence interval (CI) = 0.30-0.66), linoleic acid (OR = 0.66; 95% CI = 0.49-0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR = 0.64; 95% CI = 0.48-0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (OR = 1.65; 95% CI = 1.20-2.26), trans-ruminant palmitelaidic acid (OR = 1.51; 95% CI = 1.12-2.02), trans-industrial elaidic acid (OR = 1.52; 95% CI = 1.14-2.03), and high oleic to stearic acid ratio (OR = 2.04; 95% CI = 1.45-2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.
这项研究评估了血清磷脂脂肪酸 (PL-FAs) 和其内源性代谢标志物是否与乳腺癌 (BC) 亚型相关。EpiGEICAM 是一项西班牙多中心匹配病例对照研究。1017 名 BC 病例和健康女性对完成了生活方式和食物频率问卷。通过气相色谱-质谱法测量血清 PL-FA 百分比。使用条件和多项逻辑回归模型来量化 PL-FA 三分位与 BC 风险、总体风险和病理亚型（管腔型、HER2+ 和三阴性）的关联。还按体重指数和绝经状态进行分层分析。在 795（78%）对中测量了血清 PL-FAs。血清硬脂酸水平较高的女性（比值比（OR）=0.44；95%置信区间（CI）=0.30-0.66）、亚油酸（OR=0.66；95%CI=0.49-0.90）和花生四烯酸至二氢-γ-亚麻酸比值（OR=0.64；95%CI=0.48-0.84）的 BC 风险较低。棕榈油酸（OR=1.65；95%CI=1.20-2.26）、反刍动物棕榈烯酸（OR=1.51；95%CI=1.12-2.02）、反式工业油酸（OR=1.52；95%CI=1.14-2.03）和高油酸与硬脂酸比值（OR=2.04；95%CI=1.45-2.87）浓度较高的参与者的风险较高。这些关联在所有 BC 病理亚型中均相似。我们的研究结果强调了单独分析脂肪酸以及去饱和酶活性指数的重要性。
